ETAS®Study Results

Scientific Publications

.List of Scientific Publications

To date, universities and research institutes around the world have been involved in research on ETAS®, and about 30 papers have been published.

Heap Shock Protein (HSP)

Antioxidant

Mikio Nishizawa, et al.

Anti-inflammatory Effects of Enzyme-treated Asparagus Extract and Its Constituents in Hepatocytes

FFHD. 2016; 6(2): 91-109.

Basic
 

Tomohiro Ito, et al.

Enzyme-Treated Asparagus Extract Promotes Expression of Heat Shock Protein and Exerts Antistress Effects

J Food Sci. 2014 Mar; 79(3): H413-9.

Basic

Anti-stress

Fatigue, depression

Jun Takanari, et al.

Effect of Enzyme-Treated Asparagus Extract (ETAS) on Psychological Stress in Healthy Individuals

J Nutr Sci Vitaminol (Tokyo). 2016; 62(3): 198-205.

Clinical
Autonomic nerve

Tomohiro Ito, et al.

Effects of Enzyme-Treated Asparagus Extract on Heat Shock Protein 70, Stress Indices, and Sleep in Healthy Adult Men

J Nutr Sci Vitaminol (Tokyo). 2014; 60(4): 283-90.

Clinical
 

Tomohiro Ito, et al.

Enzyme-Treated Asparagus Extract Promotes Expression of Heat Shock Protein and Exerts Antistress Effects

J Food Sci. 2014 Mar; 79(3): H413-9.

Basic

Quality Sleep

Social jetlag

Manami Kato, et al.

Effects of Food Containing Asparagus Extract (ONR‒8)on Alertness upon Awakening and Sleep Quality on Monday in Healthy Participants with a Discrepancy between the Sleep‒wake Rhythm on Workdays and Weekends -A Randomized, Double‒blind, Placebo‒controlled, Crossover Study-

Japanese Pharmacology & Therapeutics. 2016; 44(5): 743-750.

Basic
Operating efficiency

Manami Kato, et al.

Effects of Food Containing Asparagus Extract (ONR‒8) on Sleep Conditions in Evening‒type Individuals -A Randomized, Double‒blind, Placebo‒controlled, Crossover, Exploratory Study-

Japanese Pharmacology & Therapeutics. 2016; 44(6): 887-893.

Basic
Autonomic nerve

Tomohiro Ito, et al.

Effects of Enzyme-Treated Asparagus Extract on Heat Shock Protein 70, Stress Indices, and Sleep in Healthy Adult Men

J Nutr Sci Vitaminol (Tokyo). 2014; 60(4): 283-90.

Clinical

Brain Function Improvement

Cognitive function, neurite-outgrowth

Tomoko Koda, et al.

Enzyme-treated Asparagus Extract (ETAS) Enhances Memory in Normal Rats and Induces Neurite-outgrowth in PC12 Cells

Nat Prod Commun. 2017; 12(10): 1631-1633.

Basic
Cognitive function

Junetsu Ogasawara, et al.

ETAS, an Enzyme-treated Asparagus Extract, Attenuates Amyloid β-Induced Cellular Disorder in PC12 Cells

Nat Prod Commun. 2014 Apr; 9(4): 561-4.

Basic
Cognitive function, neuroprotection

Takuya Sakurai, et al.

Enzyme-treated Asparagus officinalis Extract Shows Neuroprotective Effects and Attenuates Cognitive Impairment in Senescenceaccelerated Mice

Nat Prod Commun. 2014 Jan; 9(1): 101-6.

Basic
Cognitive function

Yin-Ching Chan, et al.

A Standardized Extract of Asparagus officinalis Stem (ETAS®) Ameliorates Cognitive Impairment, Inhibits Amyloid Deposition via BACE-1 and Normalizes Circadian Rhythm Signaling via MT1 and MT2

Nutrients. 2019 Jul 17; 11(7): 1631.

Basic

Review

 

Hiroshi Nishioka

Development of functional food ETAS from Hokkaido asparagus and establishment of sales network

Green Techno Information. 2019; 14(4), 50-53.

Review
 

Kensaku Sugaya, et al.

Proline-3-alkyldiketopiperazine from asparagus (Asparaprolines)

Development of anti-fatigue, anti-stress, and sleep-improving foods. 2020: 209-217.

Book

Other

Functional ingredient (Asparaprolines)

Shoichiro Inoue, et al.

Isolation and Structure Determination of a Heat Shock Protein Inducer, Asparagus-derived Proline-containing 3-Alkyldiketopiperazines (Asparaprolines), from a standardized extract of Asparagus officinalis stem

Nat Prod Commun. 2020; 15(3): 1-7.

Basic
Ultraviolet protection

Tomoko Koda, et al.

Effects of a Standardized Extract of Asparagus officinalis Stem on Photoaging in the Epidermal Layer of the Skin Using Cultured Keratinocytes

Nat Prod Commun. 2019; DOI: 10.1177/1934578X19857345.

Basic
Ultraviolet protection

Ken Shirato, et al.

A standardized extract of Asparagus officinalis stem prevents reduction in heat shock protein 70 expression in ultraviolet-B-irradiated normal human dermal fibroblasts: an in vitro study

Environ Health Prev Med. 2018 Aug 21; 23(1): 40.

Basic

Ken Shirato, et al.

Standardized Extract of Asparagus officinalis Stem Attenuates SARS-CoV-2 Spike Protein-Induced IL-6 and IL-1β Production by Suppressing p44/42 MAPK and Akt Phosphorylation in Murine Primary Macrophages

Molecules. 2021 Oct 14;26(20):6189.

Basic