AHCC®Standardized extract of cultured mushroom mycelia

Functional Ingredient with Scientific Evidence of its Efficacy in Immune Modulation

Since its development in 1986, the efficacy in immune modulation and the safety of AHCC®, a standardized extract of cultured Lentinula edodes mycelia, have been researched by numerous researchers and health professionals at about 100 medical institutes and universities in the world.

Study results

Scientific Publications

More than 100 universities and research facilities worldwide have conducted studies on AHCC® and published more than 100 academic papers.

.What is AHCC®?

Raw Material

AHCC® is derived from mycelia, the root-like parts of fungi which grow in the soil or on wood, while the umbrella-shaped part we generally eat as a mushroom is a fruiting body of fungi. For AHCC®, we use mycelia of Lentinula edodes, also known as “Shiitake”.

Active Components

The main component of AHCC® is alpha-glucans, including partly acylated alpha-1,4 glucans, which are unique to AHCC® derived only through our proprietary manufacturing process.

.Features of AHCC®

The proprietary long-term liquid culturing process enables us to produce consistent and standardized quality of AHCC® by culturing the specialty strain of mycelia, which we found by screening a vast range of basidiomycetes in 1987. This unique process produces special components of AHCC® that are different from other mushroom products in the market.

.Manufacturing process of AHCC®

AHCC® is manufactured by the proprietary long-term liquid culturing process unique to Amino Up. Mycelia of Shiitake mushrooms are cultured for 30 to 40 days from the preculture process to the large-size tank culture process. Then the culture liquid is concentrated, sterilized, and freeze-dried to be AHCC®. All the AHCC® bulk powder sold in the world are manufactured only at our state-of-the-art facilities in Sapporo, Japan.

.Safety of AHCC®

Toxicity Assay

・Acute oral toxicity test:LD50 > 12,500 mg/kg
・Subchronic oral toxicity study:NOAEL = 3,000 mg/kg/day
・Reverse mutation test (Ames test): Negative
・Micronucleus test: Negative

Safety Study

Human safety test (Phase I):9,000 mg/day
No serious adverse effect has been reported since its launch in 1987.


Certified as Halal

AHCC® has been certified as Halal by their authorized certification body.