ETAS®Study Results

Quality Sleep

RESEARCHImprovement of sleep quality

ETAS® improved sleep quality of inefficient sleeper and long sleepers.

Continuous ETAS® intake reduced the requency of unpleasant early-morning awakening and nightmares in males with complaints of poor sleep quality. Results from this study showed that ETAS® could improve the quality of sleep.

Tomohiro Ito et al., Journal of Nutritional Science and Vitaminology, 60(4): 283-290 (2014)

Clinical study

Design: A randomized, double-blind, placebo-controlled crossover trial
Subject: 18 healthy male volunteers (24-59 years old) concerned about sleep
Groups: ETAS®50 (n=9) and placebo (n=9)
Dose and period: 300 mg/day for 14 days (7 days x 2) with 2-week washout period
Endpoints: Evaluation of sleeping quality and time through Athens Insomnia Scale (AIS), Ogura-Shirakawa-Azumi sleep inventory MA version (OSA-MA), and Actigraph analyses


Compared to placebo, supplementation with ETAS50® improved the AIS score for “awakening earlier than desired” and reduced the frequency of dreaming and nightmares.
In addition, ETAS50® properly modulated night sleeping time in the subjects with above-average sleeping time.