ETAS®Standardized extract of asparagus stem

ETAS® is a functional ingredient made from asparagus.

Its proven HSP70 inducing effect brings various health benefits such as relieving both mental and physical stress, improving sleep quality and brain function.

Study results

Scientific Publications

To date, universities and research institutes around the world have been involved in research on ETAS®.

.What is ETAS®

Raw Material

The lower part of asparagus stems, that are cut off to unify length for shipping and normally discarded, are utilized as the raw material of ETAS®.

Active Components

Several active components are identified in ETAS® for its HSP70 inducing effect, and among all, a component group “Asparagus-derived proline-containing 3-alkyldiketopiperazines (Asparaprolines)” is set as the standard.

Shoichiro Inoue et al., Natural Product Communications, 15(3): 1-7 (2020)​

.Features of ETAS®

Oral intake of ETAS® enables to induce HSP70 expression without being exposed to such stressors.
HSP70 inducing effect of ETAS® has been proven by in vitro, in vivo and in human clinical studies.

Functions of HSP70

.Manufacturing process of ETAS®

Natural active components of asparagus are extracted with hot water and spray dried into powder.

.Safety of ETAS®

Toxicity Assay

  • Acute oral toxicity test:LD50 > 2,000 mg/kg
  • Sub chronic oral toxicity study:NOAEL = 2,000 mg/kg/day
  • Reverse mutation test (Ames test): Negative
  • Micronucleus test: Negative

Safety Study

・Human safety test (Phase I):1,500 mg/day


Certified as Kosher & Halal

ETAS® has been certified as both Kosher & Halal by their authorized certification bodies.