ETAS®Study Results
Anti-stress
RESEARCHBalancing the autonomic nervous system
ETAS® improved the condition of the autonomic nervous system (ANS) in all study endpoints.
ETAS® intake improved ANS balance*1 and kept the good balance.
Tomohiro Ito et al., Journal of Nutritional Science and Vitaminology, 60(4): 283-290 (2014)
Clinical study
Design: A randomized, double-blind, placebo-controlled trial
Subject: 20 healthy male volunteers (25-56 years old) with high stress levels during the on season
Groups: ETAS® (n=10) and placebo (n=10)
Dose and period: ETAS®50 300 mg/day for 7 days
Endpoint: Autonomic nerve estimation using Pulse Analyzer Plus TAS9
Results
The placebo group showed significant aggravations of autonomic nervous system (ANS) balance, ANS activity, and physical stress compared to baseline, while ETAS® significantly improved ANS balance and physical stress compared to placebo.
*1：ANS balance
ANS regulates various functions of human body including the activities of organs, metabolism, and body temperature. ANS consists of the sympathetic nerve, which works during activities in the daytime, and the parasympathetic nerve, which works during rest at night. Both physical and mental stresses often disrupt the balance of sympathetic activities and parasympathetic activities, and the imbalance leads to various disorders such as autonomic dystonia, neurotic gastritis, irritable bowel syndrome, hyperventilation syndrome, and so on.
RESEARCHReduction of stress related hormones
ETAS® surpressed increase of stress hormones in saliva.
The levels of stress hormones were suppressed by ETAS® intake in males with complaints of poor sleep quality. This showed possibility of ETAS® to alleviate stress.
Tomohiro Ito et al., Journal of Nutritional Science and Vitaminology, 60(4): 283-290 (2014)
Clinical study
Design: A randomized, double-blind, placebo-controlled crossover trial
Subject: 18 healthy male volunteers (24-59 years old) concerned about sleep
Groups: ETAS®50 and placebo
Dose and period: 300 mg/day for 14 days (7 days x 2) with 2-week washout period
Endpoints: Serum and salivary cortisol levels and salivary chromogranin A level
Results
Although serum and salivary cortisol levels were significantly elevated in the placebo group, the stress hormone was unalterable in the ETAS® group. In addition, ETAS® reduced salivary chromogranin A correlated with mental stress.
RESEARCHImprovement of emotional stress responses
ETAS® improved emotional stress responses including tiredness and depression.
The levels of mental stress by repeating addition of single digits were compared between before and after
continuous intake of ETAS® for 4 weeks. ETAS® increased salivary immune antibodies, and reduced tiredness and
depression. Also the quantity of responses and correct answers were increased.
ETAS® is expected to have
stress relieving effect.
Jun Takanari et al., Journal of Nutritional Science and Vitaminology, 62(3): 198-205 (2016)
Clinical study
Design: A randomized, double-blind, placebo-controlled crossover trial
Subject: 25 healthy volunteers
Groups: ETAS®50 and placebo
Dose and period: ETAS®50 300 mg/day for 56 days (28 days x 2) with 14-day washout period
Endpoints: Measurements of POMS and salivary secretory IgA (sIgA)*2 and plasma noradrenaline
levels following the Uchida-Kraepelin (U-K) test*3 as psychological stress
Results
Continuous intake of ETAS®50 showed to alleviate a feeling of fatigue and a depressive feeling, ameliorate stress indices, and elevate mental calculation score.
*2: sIgA: an antibody that plays a key role in protecting vulnerable
mucosal areas including the oral cavity and gut from invading pathogens. Levels of SIgA in saliva vary in
response to physical and psychological stress through interactions with the autonomic nervous
system.
*3： U-K: a psychological test which measures the examinee’s capability and
behavioral and personality traits based on the results of a continuous simple single-digit addition.
