AHCC®Study Results

Scientific Publications

.List of Scientific Publications

More than 100 universities and research facilities worldwide have conducted studies on AHCC and published more than 150 academic papers.

Immunity

Autoimmune disease

Francisco Karkow, et al.

AHCC® in Sjögren’s Disease: One Bold Therapeutic Hypothesis

EC Microbiol. 2020; 16(1).

Clinical
Autoimmune disease

Zaure Zhaparkhanova, et al.

Nutritional Immunotherapy in Autoimmune Thyroid Disease: Preliminary Results

Endocrinology Quick Report. 2018; 2(50): 23-27.

Clinical
Immunomodulation

Jean‑François Mallet, et al.

Active Hexose Correlated Compound (AHCC) promotes an intestinal immune response in BALB/c mice and in primary intestinal epithelial cell culture involving toll-like receptors TLR-2 and TLR-4

Eur J Nutr. 2016 Feb; 55(1): 139-46.

Basic
Immunomodulation

Loretta Olamigoke, et al.

AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation

Evid Based Complement Alternat Med. 2015; 2015:508746.

Basic
Immunomodulation

Jun Takanari, et al.

Effects of Active Hexose Correlated Compound on the Seasonal Variations of Immune Competence in Healthy Subjects

J Evid Based Complementary Altern Med. 2015 Jan; 20(1): 28-34.

Clinical
Immunomodulation

Mari Kogiso, et al.

Active Hexose Correlated Compound and T Cell Response in Hind – Limb – Unloaded BALB/c Mice

IJSR. 2015; 2(5): 32-38.

Basic
Immunomodulation

Abdelali Daddaoua, et al.

The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving TLR/MyD88 and NF-κB/MAPK activation

Food Chem. 2013 Feb 15; 136(3-4): 1288-95.

Basic
Immunomodulation

Tominori Kimura, et al.

Stabilization of human interferon-α1 mRNA by its antisense RNA

Cell Mol Life Sci. 2013 Apr; 70(8): 1451-67.

Basic
Immunomodulation

Won-Woo Lee, et al.

Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1β production from monocytes in humans

Cell Immunol. Jan-Feb 2012; 275(1-2): 19-23.

Basic
Immunomodulation

Zhinan Yin, et al.

Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor-α in healthy adults

Hum Immunol. 2010 Dec; 71(12): 1187-90.

Clinical
Immunomodulation

Naoyoshi Terakawa, et al.

Immunological Effect of Active Hexose Correlated Compound (AHCC) in Healthy Volunteers: A Double-Blind, Placebo-Controlled Trial

Nutr Cancer. 2008; 60(5): 643-51.

Clinical
Peritonitis

Katie M Love, et al.

A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis

J Trauma Acute Care Surg. 2013 Jun; 74(6): 1411-8.

Basic
Synbiotics

Abeed H Chowdhury, et al.

Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC® and Azithromycin in Healthy Individuals

Nutrients. 2019 Oct 15; 11(10): 2470.

Clinical
Synbiotics, colitis

Borja Ocón, et al.

Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis

Eur J Nutr. 2013 Mar; 52(2): 457-66.

Basic
Adenocarcinoma (pancreatic cancer, lung cancer, colon cancer)

Andrea Del Buono, et al.

Polysaccharide from Lentinus edodes for Integrative Cancer Treatment: Immunomodulatory Effects on Lymphocyte Population

WCRJ. 2016; 3 (1): e652.

Clinical
Liver cancer

Zhiyun Cao, et al.

Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-being mice

Nutr Res Pract. 2015 Apr; 9(2): 129-36.

Basic

Infectious Disease

Aspergillosis

Alba Pérez-Cantero, et al.

Increased Efficacy of Oral Fixed-Dose Combination of Amphotericin B and AHCC® Natural Adjuvant against Aspergillosis

Pharmaceutics. 2019 Sep 3; 11(9): 456.

Basic
Chlamydia

Tesfaye Belay, et al.

Active Hexose Correlated Compound Activates Immune Function to Decrease Chlamydia trachomatis Shedding in a Murine Stress Model

J Nutr Med Diet Care. 2015; 1(1): JNMDC-1-006.

Basic
Hepatitis C

Sayam Thaiudom, et al.

A study of the efficacy of Active Hexose Correlated Compound (AHCC) in the treatment of chronic Hepatitis C patients at Phramongkutklao Hospital

The Medical News (Thailand). 2010; 325: 13-16.

Clinical
HPV

Judith A Smith, et al.

AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections

Frontiers in Oncology, 12: 881902 (2022)

Clinical
HPV

Manami Misu, et al.

Clinical Effects of AHCC® on High-risk Human Papillomavirus Infection and Secretory IgA

Japanese Pharmacology & Therapeutics. 2019; 47(11): 1921-1928.

Clinical
HPV

Judith A Smith, et al.

From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections

Front Oncol. 2019 Mar 20; 9: 173.

Clinical
Influenza

Brooke E Roman, et al.

Short-term supplementation with Active Hexose Correlated Compound (AHCC) improves the antibody response to influenza B vaccine

Nutr Res. 2013 Jan; 33(1): 12-7.

Clinical
Influenza

Shoko Nogusa, et al.

Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice

Nutr Res. 2009 Feb; 29(2): 139-43.

Basic
Influenza, avian influenza, K. pneumoniae, C. albicans, P. aeruginosa, MRSA

Barry W Ritz

Supplementation with active hexose correlated compound increases survival following infectious challenge in mice

Nutr Rev. 2008 Sep; 66(9): 526-31.

Basic
Leishmaniasis

María Auxiliadora Dea-Ayuela, et al.

Nucleotides and AHCC Enhance Th1 Responses In Vitro in Leishmania-Stimulated/Infected Murine Cells

Molecules. 2020 Aug 27; 25(17): 3918.

Basic
Leishmaniasis

Rodolfo Oliveira Leal, et al.

Granulomatous rhinitis secondary to feline leishmaniosis: report of an unusual presentation and therapeutic complications

JFMS Open Rep. 2018 Nov 8; 4(2): 2055116918811374.

Veterinary
Leishmaniasis

Sergi Segarra, et al.

Prevention of disease progression in Leishmania infantum-infected dogs with dietary nucleotides and Active Hexose Correlated Compound

Parasit Vectors. 2018 Feb 21; 11(1): 103.

Veterinary
Leishmaniasis

Sergi Segarra, et al.

Randomized, allopurinol-controlled trial of the effects of dietary nucleotides and active hexose correlated compound in the treatment of canine leishmaniosis

Vet Parasitol. 2017 May 30; 239: 50-56.

Veterinary
Leishmaniasis

Sergi Segarra.

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

Microorganisms 2021, 9(12), 2601

Veterinary
Lyme disease

John Salerno, et al.

A Pilot Open-Label Study Assessing the Effects of AHCC® Supplementation on Lyme Disease Patients

BCHD. 2019; 2(11): 221-229.

Clinical
MAC lung disease

Masaki Fujita, et al.

Attenuation of Pulmonary Mycobacterium Avium Disease by Active Hexose Correlated Compound (AHCC) in Mice

J Nutr Disorders Ther. 2015; 5: 4.

Basic
Postoperative complication, K. pneumoniae

Hernan Aviles, et al.

Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection

Am J Surg. 2008 Apr; 195(4): 537-45.

Basic
West Nile fever

Shuhui Wang, et al.

Oral Administration of Active Hexose Correlated Compound Enhances Host Resistance to West Nile Encephalitis in Mice

J Nutr. 2009 Mar; 139(3): 598-602.

Basic

Cancer

Adverse effect

Daisuke Nakamoto, et al.

Active Hexose Correlated Compound (AHCC) Alleviates Gemcitabine-Induced Hematological Toxicity in Non-Tumor-Bearing Mice

Intern J Clin Med. 2012; 3: 361-367.

Basic
Adverse effect

Kota Shigama, et al.

Alleviating effect of active hexose correlated compound (AHCC) for anticancer drug-induced side effects in non-tumor-bearing mice

J Exp Ther Oncol. 2009; 8(1): 43-51.

Basic
Adverse effect

Buxiang Sun, et al.

The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents

Cancer Epidemiol. 2009 Oct; 33(3-4): 293-9.

Basic
Apoptosis, cancer stem cell

Bruna Corradetti, et al.

Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells

Integr Cancer Ther. Jan-Dec 2019; 18: 1534735419866908.

Basic
Breast cancer

Koji Wakame, et al.

Long-term administration of Active Hexose Correlated Compound as a dietary supplement to a patient after breast cancer surgery and chemotherapy: A case report

Integr. cancer sci. ther. 2017; 4(1): DOI: 10.15761/ICST.1000226

Clinical
Breast cancer

Mehran Haidari, et al.

Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC.

Life Sci. 2013 Dec 18; 93(25-26): 994-1003.

Basic
Breast cancer

Sho Hangai, et al.

Effect of Active Hexose-Correlated Compound in Women Receiving Adjuvant Chemotherapy for Breast Cancer: A Retrospective Study

J Altern Complement Med. 2013 Nov; 19(11): 905-10.

Clinical
Breast cancer

Yoichi Matsui, et al.

Retrospective Study in Breast Cancer Patients Supplemented with AHCC

Inte J Integr Oncol. 2009; 3(2): 12-16.

Clinical
Cancer stem cell, breast cancer

Émilie A Graham, et al.

MicroRNA signature in the chemoprevention of functionally-enriched stem and progenitor pools (FESPP) by Active Hexose Correlated Compound (AHCC)

Cancer Biol Ther. 2017 Oct 3; 18(10): 765-774.

Basic
Combination with immune checkpoint inhibitors, colon cancer

Insoo Kang, et al.

AHCC®, a standardized extract of cultured Lentinula edodes mycelia, promotes the anti-tumor effect of dual immune checkpoint blockade effect in murine colon cancer

Frontiers in Immunology, 13: 875872 (2022)

Basic
Colon cancer

Maiko Takahashi, et al.

Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured Lentinula edodes mycelia

J Clin Biochem Nutr. 2019 Nov; 65(3): 203-208.

Basic
Colon cancer, pancreatic cancer, lung cancer, ovarian cancer

Toshinori Ito, et al.

Reduction of Adverse Effects by a Mushroom Product, Active Hexose Correlated Compound (AHCC) in Patients with Advanced Cancer during Chemotherapy-The Significance of the Levels of HHV-6 DNA in Saliva as a Surrogate Biomarker during Chemotherapy.

Nutr Cancer. 2014; 66(3): 377-82.

Clinical
Drug interaction, breast cancer

Lata Mathew, et al.

Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models

Integr Cancer Ther. 2017 Sep; 16(3): 300-307.

Basic
Drug interaction, ovarian cancer

Rodney J Hunter, et al.

Evaluation of active hexose correlated compound (AHCC) in combination with pegylated liposomal doxorubicin for treatment of ovarian cancer

Int J Appl Res Nat Prod. 2011; 4(3): 6-14.

Basic
Gastric cancer, colon cancer

Yusai Kawaguchi

Improved Survival of Patients with Gastric Cancer or Colon Cancer when treated with Active Hexose Correlated Compound (AHCC): Effect of AHCC on digestive system cancer

Natural Medicine Journal. 2009; 1(1).

Clinical
Head and neck cancer

Dillip Kumar Parida, et al.

Integrating Complimentary and Alternative Medicine in Form of Active Hexose Correlated Compound (AHCC) in the Management of Head & Neck Cancer Patients

Intern J Clin Med. 2011; 2, 588-592.

Clinical
Leukemia

Kavin Fatehchand, et al.

Active hexose-correlated compound enhances extrinsic-pathway-mediated apoptosis of Acute Myeloid Leukemic cells

PLoS One. 2017 Jul 20; 12(7): e0181729.

Basic
Lung cancer

Reiki Ishizuka, et al.

Personalized Cancer Therapy for Stage IV Lung Cancer: Combined Use of Active Hexose Correlated Compound and Genistein Concentrated Polysaccharide

Pers Med Univers. 2012; 1(1): 39-44.

Clinical
Lung cancer, breast cancer

Reiki Ishizuka, et al.

Review of Cancer Therapy with AHCC(R) and GCP(R); The Long-Term Follow-Up over 12 Years for Stage IV (M1) Cancer of the Lung and the Breast

International Journal of Integrative Medicine. 2010; 2(1): 98-111.

Clinical
Malignant melanoma

Rosa Mistica Ignacio, et al.

Therapeutic effect of Active Hexose-Correlated Compound (AHCC) combined with CpG-ODN (oligodeoxynucleotide) in B16 melanoma murine model

Cytokine. 2015 Dec; 76(2): 131-137.

Basic
Ovarian cancer

Jin Young Choia, et al.

Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation

Nutr Cancer. 2018 Jan; 70(1): 109-115.

Basic
Ovarian cancer

Wineeya Suknikhom, et al.

The Effects of Active Hexose Correlated Compound (AHCC) on Levels of CD4+ and CD8+ in Patients with Epithelial Ovarian Cancer or Peritoneal Cancer Receiving Platinum Based Chemotherapy

Asian Pac J Cancer Prev. 2017 Mar 1; 18(3): 633-638.

Clinical
Pancreatic cancer

Anarkhuu Bold-Erdene, et al.

Clinical outcomes of active hexose correlated compound (AHCC®) and its effect on chemotherapy related adverse events in patients with unresectable pancreatic cancer

Diagnosis. 2018; 83(3): 56-60.

Clinical
Pancreatic cancer

Keisuke Kuhara, et al.

CUB Domain-containing Protein 1 (CDCP1) Is Down-regulated by Active Hexose-correlated Compound in Human Pancreatic Cancer Cells

Anticancer Res. 2018 Nov; 38(11): 6107-6111.

Basic
Pancreatic cancer

Hiroaki Yanagimoto, et al.

Alleviating effect of Active Hexose Correlated Compound (AHCC) on chemotherapy-related adverse events in patients with unresectable pancreatic ductal adenocarcinoma

Nutr Cancer. 2016; 68(2): 234-40.

Clinical
Pancreatic cancer

Masayuki Tokunaga, et al.

Active Hexose-correlated Compound Down-regulates Heat Shock Factor 1, a Transcription Factor for HSP27, in Gemcitabine-resistant Human Pancreatic Cancer Cells

Anticancer Res. 2015 Nov; 35(11): 6063-7.

Basic
Pancreatic cancer

Junya Nawata, et al.

Active Hexose-correlated Compound Down-regulates Sex-determining Region Y-box 2 of Pancreatic Cancer Cells

Anticancer Res. 2014 Sep; 34(9): 4807-11.

Basic
Pancreatic cancer

Shigeyuki Suenaga, et al.

Active Hexose-correlated Compound Down-regulates HSP27 of Pancreatic Cancer Cells, and Helps the Cytotoxic Effect of Gemcitabine

Anticancer Res. 2014 Jan; 34(1): 141-6.

Basic
Prostate cancer

Yoshiteru Sumiyoshi, et al.

Dietary Administration of Mushroom Mycelium Extracts in Patients with Early Stage Prostate Cancers Managed Expectantly: A Phase II Study

Jpn J Clin Oncol. 2010 Oct; 40(10): 967-72.

Clinical
Prostate cancer

Jeffrey Turner, et al.

Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer

Anticancer Drugs. 2009 Mar; 20(3): 215-6.

Clinical
Salivary gland cancer

Tamer A Badawi, et al.

Immunoprophylactic Effect of Active Hexose Correlated Compound on Normal and Induced Submandibular Salivary Gland Neoplasm in Albino Rats

Cairo Dental Journal. 2012; 28(1): 485-490.

Basic
Adenocarcinoma (pancreatic cancer, lung cancer, colon cancer)

Andrea Del Buono, et al.

Polysaccharide from Lentinus edodes for Integrative Cancer Treatment: Immunomodulatory Effects on Lymphocyte Population

WCRJ. 2016; 3 (1): e652.

Clinical
Liver cancer

Zhiyun Cao, et al.

Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-being mice

Nutr Res Pract. 2015 Apr; 9(2): 129-36.

Basic

Other

Alcoholic fatty liver

Hyangkyoung Kim, et al.

Effect of Active Hexose Correlated Compound (AHCC) in Alcohol-Induced Liver Enzyme Elevation

J Nutr Sci Vitaminol (Tokyo). 2014; 60(5): 348-56.

Clinical
Autonomic nerve

Jun Takanari, et al.

Effects of AHCC® on Immune and Stress Responses in Healthy Individuals

J Evid Based Integr Med. Jan-Dec 2018; 23: 2156587218756511.

Clinical
Colitis

Cristina Mascaraque, et al.

Active hexose correlated compound exerts therapeutic effects in lymphocyte driven colitis

Mol Nutr Food Res. 2014 Dec; 58(12): 2379-82.

Basic
Drug interaction

Rachel E. Carlson, et al.

Screening for potential pathways of drug-supplement interactions between AHCC® and common medications

IJNF. 2018; 4(5): 32-36.

Basic
Drug interaction

Larry W Coffer, et al.

Evaluation of active hexose correlated compound (AHCC) on phase II drug metabolism pathways and the implications for supplement-drug interactions

J Integr Oncol. 2015; doi:10.4172/2329-6771.1000142.

Basic
Drug interaction

Claire M Mach, et al.

Evaluation of Active Hexose Correlated Compound Hepatic Metabolism and Potential for Drug Interactions with Chemotherapy Agents

J Soc Integr Oncol. Summer 2008; 6(3): 105-9.

Basic
Gene expression profiling

Koji Wakame, et al.

DNA microarray analysis of gene expression changes in ICR mouse liver following treatment with active hexose correlated compound

Integr Mol Med. 2016; 3(3): 739-744.

Basic
Hepatitis

Yoshito Tanaka, et al.

Adenosine, a hepato-protective component in active hexose correlated compound: Its identification and iNOS suppression mechanism

Nitric Oxide. 2014 Aug 31; 40: 75-86.

Basic
Hepatitis

Kosuke Matsui, et al.

Active Hexose Correlated Compound Inhibits the Expression of Proinflammatory Biomarker iNOS in Hepatocytes

Eur Surg Res. 2011; 47(4): 274-83.

Basic
Hepatitis

Tadayoshi Okumura, et al.

Inhibition of iNOS induction by functional food AHCC (Screening of food with “hepatoprotective effect” using in vitro hepatocytes)

Journal of the Japanese Society of Food Engineering. 2010; 30(3): 100-106.

Basic
Infantile epilepsy

Natalia V Mikhailichenko, et al.

An open label trial of a standardized extract of cultured Lentinula edodes mycelia (ECLM) in children with refractory epilepsy

FFHD. 2019; 9(3): 145-156.

Clinical
Ischemia-reperfusion injury

Yosuke Ueyama, et al.

Active Hexose Correlated Compound Has Protective Effects in Ischemia-Reperfusion Injury of the Rat Small Intestine

J Surg Res. 2019 Nov; 243: 265-273.

Basic
Liver disorder

Richi Nakatake, et al.

Protective effects of active hexose correlated compound in a rat model of liver injury after hepatectomy

FFHD. 2016; 6(11): 702-717.

Basic
Longevity (nematode)

Tetsuya Okuyama, et al.

Active Hexose Correlated Compound Extends the Lifespan and Increases the Thermotolerance of Nematodes

FFHD. 2013; 3(6):166-182.

Basic
Muscle atrophy

Young-Ju Song, et al.

AHCC Supplementation Attenuates Muscle Atrophy via Akt Activation in Hindlimb-suspended Rat

Biotechnol Bioprocess Eng. 2019; 24: 476-482.

Basic
Sepsis

Marie-Francoise Doursout, et al.

Active hexose correlated compound modulates LPS-induced hypotension and gut injury in rats

Int Immunopharmacol. 2016 Oct; 39: 280-286.

Basic

Hajime Fujii, et al.

Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC)

Regul Toxicol Pharmacol. 2011 Mar; 59(2): 237-50.

Basic

Review

Allergic disease, autoimmune disease, lifestyle disease

Manami Misu, et al.

Various functions of AHCC® – Case Report

New Food Industry. 2017; 59(2): 14-21.

Review
Complementary therapy

Jun-Young Choi

Complementary Therapy for Improvement of Quality of Life in Cancer Patients

J Korean Med Assoc. 2008; 51(5): 435-448.

Review
Immunity

Min Sun Shin, et al.

The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies

J Immunol Res. 2019 Dec 20; 2019: 3758576

Review
Immunity

Hiroshi Nishioka, et al.

Potentiating action of AHCC on natural immunity

Medical Science Digest. 2009; 35(6): 241-244.

Basic
Infection, COVID-19

Francesco Di Pierro, et al.

Possible therapeutic role of a highly standardized mixture of active compounds derived from cultured Lentinula edodes mycelia (AHCC) in patients infected with 2019 novel coronavirus

Minerva Gastroenterol Dietol. 2020 Jun; 66(2): 172-176.

Review
Pet animal

Yutaka Horiuchi, et al.

Complementary and Alternative Medicine and AHCC®, GCP® in Companion Animals

Companion Animal Practice. 2012; 4: 53-57.

Veterinary
Pet animal

Takashi Nishizawa, et al.

Alpha Glucan (AHCC Liquid) Activates Macrophages More than Beta Glucan – Prospects for Basidiomycetes

Companion Animal Practice. 2011 Apr.

Veterinary
Pet animal

Mamoru Onuma, et al.

The supplementation therapy of caine dermatology in my hospital

Japanese Journal of Small Animal Practice. 2008; 27(6): 340-346.

Veterinary
Prostate cancer

Philippa J Cheetham, et al.

Diet and prostate cancer – a holistic approach to management

Arch Esp Urol. 2011 Oct; 64(8): 720-34.

Review

Mikio Nishizawa, et al.

Assessment of anti-inflammatory effects of Japanese Kampo medicine versus functional foods

FFHD. 2019; 9(2): 79-91.

Review

Hiroshi Nishioka, et al.

Various functions of a standardized extract of cultured Lentinula edodes mycelia (AHCC®)

Medical Science Digest. 2019; 45(2): 127-130.

Review

Koji Wakame

Research and functional development of basidiomycete culture extracts

Agricultural biotechnology. 2017; 1(4): 438-442.

Review

Robert M Hackman, et al.

Forecasting Nutrition Research in 2020

J Am Coll Nutr. 2014; 33(4): 340-6.

Review

Catherine Ulbricht, et al.

An Evidence-Based Systematic Review of Active Hexose Correlated Compound (AHCC) by the Natural Standard Research Collaboration

J Diet Suppl. 2013 Sep; 10(3): 264-308.

Review

Yasuo Kamiyama

AHCC: basic and clinical research

Journal of the society tropical resources technologists. 2011; 27(1): 1-8.

Review

Shinil K Shah, et al.

An Evidence-Based Review of a Lentinula edodes Mushroom Extract as Complementary Therapy in the Surgical Oncology Patient

J Parenter Enteral Nutr. 2011 Jul; 35(4): 449-58.

Review

Barry W Ritz

Active Hexose Correlated Compound (AHCC) and Immune Outcomes in Humans: A Review

Natural Medicine Journal. 2011; 3(1): 3-7.

Review

Takehito Miura, et al.

Basic and Clinical Studies on Active Hexose Correlated Compound

Biotechnology in Functional Foods and Nutraceuticals. 2010: 51-58.

Book

Takehito Miura, et al.

Basic and Clinical Studies on AHCC —Recent Topics—

Japanese Journal of Complementary and Alternative Medicine. 2009; 6(1): 1-7.

Review

Kentaro Kitadate

Augmentation of Anticancer Activity and Attenuation of Side Effect by AHCC

FOOD Style 21. 2008; 132: 69-72.

Basic