AHCC®

論文

THESIS研究論文一覧

これまで世界100以上の大学・研究機関でAHCCに関する研究が手掛けられ、150以上もの論文が発表されています。

免疫

免疫調節

Jean‑François Mallet, et al.

Active Hexose Correlated Compound (AHCC) promotes an intestinal immune response in BALB/c mice and in primary intestinal epithelial cell culture involving toll-like receptors TLR-2 and TLR-4

Eur J Nutr. 2016 Feb; 55(1): 139-46.

臨床

Loretta Olamigoke, et al.

AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation

Evid Based Complement Alternat Med. 2015; 2015:508746.

基礎

Jun Takanari, et al.

Effects of Active Hexose Correlated Compound on the Seasonal Variations of Immune Competence in Healthy Subjects

J Evid Based Complementary Altern Med. 2015 Jan; 20(1): 28-34.

基礎

Abdelali Daddaoua, et al.

The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving TLR/MyD88 and NF-κB/MAPK activation

Food Chem. 2013 Feb 15; 136(3-4): 1288-95.

臨床

Tominori Kimura, et al.

Stabilization of human interferon-α1 mRNA by its antisense RNA

Cell Mol Life Sci. 2013 Apr; 70(8): 1451-67.

基礎

Won-Woo Lee, et al.

Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1β production from monocytes in humans

Cell Immunol. Jan-Feb 2012; 275(1-2): 19-23.

臨床

Zhinan Yin, et al.

Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor-α in healthy adults

Hum Immunol. 2010 Dec; 71(12): 1187-90.

臨床

Naoyoshi Terakawa, et al.

Immunological Effect of Active Hexose Correlated Compound (AHCC) in Healthy Volunteers: A Double-Blind, Placebo-Controlled Trial

Nutr Cancer. 2008; 60(5): 643-51.

臨床

Mari Kogiso, et al.

Active Hexose Correlated Compound and T Cell Response in Hind – Limb – Unloaded BALB/c Mice

IJSR. 2015; 2(5): 32-38.

基礎
自己免疫疾患

Francisco Karkow, et al.

AHCC® in Sjögren’s Disease: One Bold Therapeutic Hypothesis

EC Microbiol. 2020; 16(1).

臨床

Zaure Zhaparkhanova, et al.

自己免疫性甲状腺疾患における栄養免疫療法:予備試験結果

内分泌学速報. 2018; 2(50): 23-27.

臨床
腹膜炎

Katie M Love, et al.

A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis

J Trauma Acute Care Surg. 2013 Jun; 74(6): 1411-8.

臨床
シンバイオティクス・大腸炎

Borja Ocón, et al.

Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis

Eur J Nutr. 2013 Mar; 52(2): 457-66.

基礎
シンバイオティクス

Abeed H Chowdhury, et al.

Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC® and Azithromycin in Healthy Individuals

Nutrients. 2019 Oct 15; 11(10): 2470.

基礎
腺がん(膵臓、肺、大腸がん)

Andrea Del Buono, et al.

Polysaccharide from Lentinus edodes for Integrative Cancer Treatment: Immunomodulatory Effects on Lymphocyte Population

WCRJ. 2016; 3 (1): e652.

基礎
肝臓がん

Zhiyun Cao, et al.

Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-being mice

Nutr Res Pract. 2015 Apr; 9(2): 129-36.

総説

感染症

インフルエンザ

Brooke E Roman, et al.

Short-term supplementation with Active Hexose Correlated Compound (AHCC) improves the antibody response to influenza B vaccine

Nutr Res. 2013 Jan; 33(1): 12-7.

総説

Shoko Nogusa, et al.

Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice

Nutr Res. 2009 Feb; 29(2): 139-43.

獣医
インフルエンザ、鳥インフルエンザ、肺炎桿菌、カンジダ、緑濃菌、MRSA

Barry W Ritz

Supplementation with active hexose correlated compound increases survival following infectious challenge in mice

Nutr Rev. 2008 Sep; 66(9): 526-31.

総説
HPV

三栖茉奈美ら

ハイリスク型ヒトパピローマウイルス感染と分泌型IgA に対するAHCC®の臨床効果

薬理と治療. 2019; 47(11): 1921-1928.

書籍

Judith A Smith, et al.

From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections

Front Oncol. 2019 Mar 20; 9: 173.

基礎
リーシュマニア症

María Auxiliadora Dea-Ayuela, et al.

Nucleotides and AHCC Enhance Th1 Responses In Vitro in Leishmania-Stimulated/Infected Murine Cells

Molecules. 2020 Aug 27; 25(17): 3918.

総説

Rodolfo Oliveira Leal, et al.

Granulomatous rhinitis secondary to feline leishmaniosis: report of an unusual presentation and therapeutic complications

JFMS Open Rep. 2018 Nov 8; 4(2): 2055116918811374.

総説

Sergi Segarra, et al.

Prevention of disease progression in Leishmania infantum-infected dogs with dietary nucleotides and Active Hexose Correlated Compound

Parasit Vectors. 2018 Feb 21; 11(1): 103.

総説

Sergi Segarra, et al.

Randomized, allopurinol-controlled trial of the effects of dietary nucleotides and active hexose correlated compound in the treatment of canine leishmaniosis

Vet Parasitol. 2017 May 30; 239: 50-56.

総説

Sergi Segarra.

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

Microorganisms 2021, 9(12), 2601

総説
ライム病

John Salerno, et al.

A Pilot Open-Label Study Assessing the Effects of AHCC® Supplementation on Lyme Disease Patients

BCHD. 2019; 2(11): 221-229.

総説
肺MAC症

Masaki Fujita, et al.

Attenuation of Pulmonary Mycobacterium Avium Disease by Active Hexose Correlated Compound (AHCC) in Mice

J Nutr Disorders Ther. 2015; 5: 4.

総説
西ナイル熱

Shuhui Wang, et al.

Oral Administration of Active Hexose Correlated Compound Enhances Host Resistance to West Nile Encephalitis in Mice

J Nutr. 2009 Mar; 139(3): 598-602.

総説
術後合併症・肺炎桿菌

Hernan Aviles, et al.

Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection

Am J Surg. 2008 Apr; 195(4): 537-45.

総説
クラミジア

Tesfaye Belay, et al.

Active Hexose Correlated Compound Activates Immune Function to Decrease Chlamydia trachomatis Shedding in a Murine Stress Model

J Nutr Med Diet Care. 2015; 1(1): JNMDC-1-006.

獣医
アスペルギルス症

Alba Pérez-Cantero, et al.

Increased Efficacy of Oral Fixed-Dose Combination of Amphotericin B and AHCC® Natural Adjuvant against Aspergillosis

Pharmaceutics. 2019 Sep 3; 11(9): 456.

総説
C型肝炎

Sayam Thaiudom, et al.

A study of the efficacy of Active Hexose Correlated Compound (AHCC) in the treatment of chronic Hepatitis C patients at Phramongkutklao Hospital

The Medical News (Thailand). 2010; 325: 13-16.

総説

がん

膵臓がん

Anarkhuu Bold-Erdene, et al.

Clinical outcomes of active hexose correlated compound (AHCC®) and its effect on chemotherapy related adverse events in patients with unresectable pancreatic cancer

Diagnosis. 2018; 83(3): 56-60.

臨床

Keisuke Kuhara, et al.

CUB Domain-containing Protein 1 (CDCP1) Is Down-regulated by Active Hexose-correlated Compound in Human Pancreatic Cancer Cells

Anticancer Res. 2018 Nov; 38(11): 6107-6111.

基礎

Hiroaki Yanagimoto, et al.

Alleviating effect of Active Hexose Correlated Compound (AHCC) on chemotherapy-related adverse events in patients with unresectable pancreatic ductal adenocarcinoma

Nutr Cancer. 2016; 68(2): 234-40.

基礎

Masayuki Tokunaga, et al.

Active Hexose-correlated Compound Down-regulates Heat Shock Factor 1, a Transcription Factor for HSP27, in Gemcitabine-resistant Human Pancreatic Cancer Cells

Anticancer Res. 2015 Nov; 35(11): 6063-7.

基礎

Junya Nawata, et al.

Active Hexose-correlated Compound Down-regulates Sex-determining Region Y-box 2 of Pancreatic Cancer Cells

Anticancer Res. 2014 Sep; 34(9): 4807-11.

基礎

Shigeyuki Suenaga, et al.

Active Hexose-correlated Compound Down-regulates HSP27 of Pancreatic Cancer Cells, and Helps the Cytotoxic Effect of Gemcitabine

Anticancer Res. 2014 Jan; 34(1): 141-6.

臨床
乳がん

Koji Wakame, et al.

Long-term administration of Active Hexose Correlated Compound as a dietary supplement to a patient after breast cancer surgery and chemotherapy: A case report

Integr. cancer sci. ther. 2017; 4(1): DOI: 10.15761/ICST.1000226

基礎

Mehran Haidari, et al.

Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC.

Life Sci. 2013 Dec 18; 93(25-26): 994-1003.

基礎

Sho Hangai, et al.

Effect of Active Hexose-Correlated Compound in Women Receiving Adjuvant Chemotherapy for Breast Cancer: A Retrospective Study

J Altern Complement Med. 2013 Nov; 19(11): 905-10.

臨床

Yoichi Matsui, et al.

Retrospective Study in Breast Cancer Patients Supplemented with AHCC

Inte J Integr Oncol. 2009; 3(2): 12-16.

臨床
抗がん剤副作用

Kota Shigama, et al.

Alleviating effect of active hexose correlated compound (AHCC) for anticancer drug-induced side effects in non-tumor-bearing mice

J Exp Ther Oncol. 2009; 8(1): 43-51.

基礎

Buxiang Sun, et al.

The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents

Cancer Epidemiol. 2009 Oct; 33(3-4): 293-9.

基礎

Daisuke Nakamoto, et al.

Active Hexose Correlated Compound (AHCC) Alleviates Gemcitabine-Induced Hematological Toxicity in Non-Tumor-Bearing Mice

Intern J Clin Med. 2012; 3: 361-367.

基礎
卵巣がん

Jin Young Choia, et al.

Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation

Nutr Cancer. 2018 Jan; 70(1): 109-115.

臨床

Wineeya Suknikhom, et al.

The Effects of Active Hexose Correlated Compound (AHCC) on Levels of CD4+ and CD8+ in Patients with Epithelial Ovarian Cancer or Peritoneal Cancer Receiving Platinum Based Chemotherapy

Asian Pac J Cancer Prev. 2017 Mar 1; 18(3): 633-638.

基礎
前立腺がん

Yoshiteru Sumiyoshi, et al.

Dietary Administration of Mushroom Mycelium Extracts in Patients with Early Stage Prostate Cancers Managed Expectantly: A Phase II Study

Jpn J Clin Oncol. 2010 Oct; 40(10): 967-72.

臨床

Jeffrey Turner, et al.

Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer

Anticancer Drugs. 2009 Mar; 20(3): 215-6.

基礎
大腸がん

Insoo Kang, et al.

AHCC®, a standardized extract of cultured Lentinula edodes mycelia, promotes the anti-tumor effect of dual immune checkpoint blockade effect in murine colon cancer

Frontiers in Immunology, 13: 875872 (2022)

基礎

Maiko Takahashi, et al.

Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured Lentinula edodes mycelia

J Clin Biochem Nutr. 2019 Nov; 65(3): 203-208.

基礎
肺がん、乳がん

Reiki Ishizuka, et al.

Review of Cancer Therapy with AHCC(R) and GCP(R); The Long-Term Follow-Up over 12 Years for Stage IV (M1) Cancer of the Lung and the Breast

国際統合医学会誌. 2010; 2(1): 98-111.

基礎
肺がん

Reiki Ishizuka, et al.

Personalized Cancer Therapy for Stage IV Lung Cancer: Combined Use of Active Hexose Correlated Compound and Genistein Concentrated Polysaccharide

Pers Med Univers. 2012; 1(1): 39-44.

基礎
薬物相互作用・卵巣がん

Rodney J Hunter, et al.

Evaluation of active hexose correlated compound (AHCC) in combination with pegylated liposomal doxorubicin for treatment of ovarian cancer

Int J Appl Res Nat Prod. 2011; 4(3): 6-14.

基礎
薬物相互作用・乳がん

Lata Mathew, et al.

Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models

Integr Cancer Ther. 2017 Sep; 16(3): 300-307.

基礎
腺がん(膵臓、肺、大腸がん)

Andrea Del Buono, et al.

Polysaccharide from Lentinus edodes for Integrative Cancer Treatment: Immunomodulatory Effects on Lymphocyte Population

WCRJ. 2016; 3 (1): e652.

基礎
肝臓がん

Zhiyun Cao, et al.

Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-being mice

Nutr Res Pract. 2015 Apr; 9(2): 129-36.

総説
胃、大腸がん

Yusai Kawaguchi

Improved Survival of Patients with Gastric Cancer or Colon Cancer when treated with Active Hexose Correlated Compound (AHCC): Effect of AHCC on digestive system cancer

Natural Medicine Journal. 2009; 1(1).

臨床
白血病

Kavin Fatehchand, et al.

Active hexose-correlated compound enhances extrinsic-pathway-mediated apoptosis of Acute Myeloid Leukemic cells

PLoS One. 2017 Jul 20; 12(7): e0181729.

臨床
頭頸部がん

Dillip Kumar Parida, et al.

Integrating Complimentary and Alternative Medicine in Form of Active Hexose Correlated Compound (AHCC) in the Management of Head & Neck Cancer Patients

Intern J Clin Med. 2011; 2, 588-592.

臨床
唾液腺がん

Tamer A Badawi, et al.

Immunoprophylactic Effect of Active Hexose Correlated Compound on Normal and Induced Submandibular Salivary Gland Neoplasm in Albino Rats

Cairo Dental Journal. 2012; 28(1): 485-490.

基礎
大腸、膵臓、肺、卵巣がん

Toshinori Ito, et al.

Reduction of Adverse Effects by a Mushroom Product, Active Hexose Correlated Compound (AHCC) in Patients with Advanced Cancer during Chemotherapy-The Significance of the Levels of HHV-6 DNA in Saliva as a Surrogate Biomarker during Chemotherapy.

Nutr Cancer. 2014; 66(3): 377-82.

基礎
がん幹細胞・乳がん

Émilie A Graham, et al.

MicroRNA signature in the chemoprevention of functionally-enriched stem and progenitor pools (FESPP) by Active Hexose Correlated Compound (AHCC)

Cancer Biol Ther. 2017 Oct 3; 18(10): 765-774.

基礎
アポトーシス・がん幹細胞

Bruna Corradetti, et al.

Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells

Integr Cancer Ther. Jan-Dec 2019; 18: 1534735419866908.

基礎
悪性黒色腫

Rosa Mistica Ignacio, et al.

Therapeutic effect of Active Hexose-Correlated Compound (AHCC) combined with CpG-ODN (oligodeoxynucleotide) in B16 melanoma murine model

Cytokine. 2015 Dec; 76(2): 131-137.

基礎

その他

肝炎

Yoshito Tanaka, et al.

Adenosine, a hepato-protective component in active hexose correlated compound: Its identification and iNOS suppression mechanism

Nitric Oxide. 2014 Aug 31; 40: 75-86.

臨床

Kosuke Matsui, et al.

Active Hexose Correlated Compound Inhibits the Expression of Proinflammatory Biomarker iNOS in Hepatocytes

Eur Surg Res. 2011; 47(4): 274-83.

臨床

奥村忠芳ら

機能性食品AHCCによるiNOS誘導の阻害(in vitro肝細胞を用いた”肝保護効果”を持つ食品のスクリーニング)

食品加工技術. 2010; 30(3): 100-106.

基礎
薬物相互作用

Larry W Coffer, et al.

Evaluation of active hexose correlated compound (AHCC) on phase II drug metabolism pathways and the implications for supplement-drug interactions

J Integr Oncol. 2015; doi:10.4172/2329-6771.1000142.

基礎

Claire M Mach, et al.

Evaluation of Active Hexose Correlated Compound Hepatic Metabolism and Potential for Drug Interactions with Chemotherapy Agents

J Soc Integr Oncol. Summer 2008; 6(3): 105-9.

基礎

Rachel E. Carlson, et al.

Screening for potential pathways of drug-supplement interactions between AHCC® and common medications

IJNF. 2018; 4(5): 32-36.

基礎
敗血症

Marie-Francoise Doursout, et al.

Active hexose correlated compound modulates LPS-induced hypotension and gut injury in rats

Int Immunopharmacol. 2016 Oct; 39: 280-286.

臨床
大腸炎

Cristina Mascaraque, et al.

Active hexose correlated compound exerts therapeutic effects in lymphocyte driven colitis

Mol Nutr Food Res. 2014 Dec; 58(12): 2379-82.

基礎
自律神経

Jun Takanari, et al.

Effects of AHCC® on Immune and Stress Responses in Healthy Individuals

J Evid Based Integr Med. Jan-Dec 2018; 23: 2156587218756511.

基礎
小児てんかん

Natalia V Mikhailichenko, et al.

An open label trial of a standardized extract of cultured Lentinula edodes mycelia (ECLM) in children with refractory epilepsy

FFHD. 2019; 9(3): 145-156.

基礎
筋力維持

Young-Ju Song, et al.

AHCC Supplementation Attenuates Muscle Atrophy via Akt Activation in Hindlimb-suspended Rat

Biotechnol Bioprocess Eng. 2019; 24: 476-482.

基礎
虚血再灌流傷害

Yosuke Ueyama, et al.

Active Hexose Correlated Compound Has Protective Effects in Ischemia-Reperfusion Injury of the Rat Small Intestine

J Surg Res. 2019 Nov; 243: 265-273.

臨床
肝障害

Richi Nakatake, et al.

Protective effects of active hexose correlated compound in a rat model of liver injury after hepatectomy

FFHD. 2016; 6(11): 702-717.

基礎
延命(線虫)

Tetsuya Okuyama, et al.

Active Hexose Correlated Compound Extends the Lifespan and Increases the Thermotolerance of Nematodes

FFHD. 2013; 3(6):166-182.

基礎
遺伝子発現解析

Koji Wakame, et al.

DNA microarray analysis of gene expression changes in ICR mouse liver following treatment with active hexose correlated compound

Integr Mol Med. 2016; 3(3): 739-744.

基礎
アルコール性脂肪肝

Hyangkyoung Kim, et al.

Effect of Active Hexose Correlated Compound (AHCC) in Alcohol-Induced Liver Enzyme Elevation

J Nutr Sci Vitaminol (Tokyo). 2014; 60(5): 348-56.

臨床

Hajime Fujii, et al.

Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC)

Regul Toxicol Pharmacol. 2011 Mar; 59(2): 237-50.

基礎

総説

免疫

Min Sun Shin, et al.

The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies

J Immunol Res. 2019 Dec 20; 2019: 3758576

基礎

西岡浩ら

AHCCの自然免疫増強作用

メディカル・サイエンス・ダイジェスト. 2009; 35(6): 241-244.

総説
補完代替医療

Jun-Young Choi

Complementary Therapy for Improvement of Quality of Life in Cancer Patients

J Korean Med Assoc. 2008; 51(5): 435-448.

獣医
前立腺がん

Philippa J Cheetham, et al.

Diet and prostate cancer – a holistic approach to management

Arch Esp Urol. 2011 Oct; 64(8): 720-34.

臨床
感染症・COVID-19

Francesco Di Pierro, et al.

Possible therapeutic role of a highly standardized mixture of active compounds derived from cultured Lentinula edodes mycelia (AHCC) in patients infected with 2019 novel coronavirus

Minerva Gastroenterol Dietol. 2020 Jun; 66(2): 172-176.

基礎
アレルギー疾患・自己免疫疾患・生活習慣病

三栖茉奈美ら

AHCC®の多様な機能性 ~症例報告~

New Food Industry. 2017; 59(2): 14-21.

臨床
動物(ペット)

堀内大ら

コンパニオンアニマルにおける補完代替医療とAHCC®,GCP®

CAP. 2012; 4: 53-57.

基礎

西澤孝志ら

βグルカンよりもαグルカン(担子菌由来AHCC 配合リキッド)がマクロファージを活性化させる ~担がん動物への展望~

CAP. 2011 Apr.

基礎

小沼守ら

当院の犬皮膚科におけるサプリメント療法

小動物臨床. 2008; 27(6): 340-346.

臨床

上山泰男

食品AHCCの機能性について―基礎と臨床―

南方資源利用技術研究会誌. 2011; 27(1): 1-8.

臨床

Mikio Nishizawa, et al.

Assessment of anti-inflammatory effects of Japanese Kampo medicine versus functional foods

FFHD. 2019; 9(2): 79-91.

獣医

西岡浩ら

担子菌培養抽出物(AHCC®)の多様な機能性

メディカル・サイエンス・ダイジェスト. 2019; 45(2): 127-130.

獣医

若命浩二

菌類培養液の研究と機能性開発

アグリバイオ. 2017; 1(4): 438-442.

獣医

Robert M Hackman, et al.

Forecasting Nutrition Research in 2020

J Am Coll Nutr. 2014; 33(4): 340-6.

基礎

Catherine Ulbricht, et al.

An Evidence-Based Systematic Review of Active Hexose Correlated Compound (AHCC) by the Natural Standard Research Collaboration

J Diet Suppl. 2013 Sep; 10(3): 264-308.

基礎

Shinil K Shah, et al.

An Evidence-Based Review of a Lentinula edodes Mushroom Extract as Complementary Therapy in the Surgical Oncology Patient

J Parenter Enteral Nutr. 2011 Jul; 35(4): 449-58.

臨床

Barry W Ritz

Active Hexose Correlated Compound (AHCC) and Immune Outcomes in Humans: A Review

Natural Medicine Journal. 2011; 3(1): 3-7.

臨床

Takehito Miura, et al.

Basic and Clinical Studies on Active Hexose Correlated Compound

Biotechnology in Functional Foods and Nutraceuticals. 2010: 51-58.

基礎

三浦健人ら

AHCCの基礎と臨床 ―最近の話題―

日本補完代替医療学会誌. 2009; 6(1): 1-7.

基礎

北館健太郎

AHCCの抗がん活性増強と副作用軽減効果

FOOD STYLE 21. 2008; 132: 69-72.

基礎

研究データと実績