Oligonol®Study Results
Scientific Publications
.List of Scientific Publications
To date, universities and research institutes around the world have been engaged in research on Oligonol®, and more than 100 papers have been published.
Exercise and sport
Exercise performance | Aki Kawamura, et al. Phys Act Nutr. 2021; 25(3): 8-15. | Clinical |
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Exercise performance | Seung Wan Kang, et al. J Clin Biochem Nutr. 2012; 50(2): 106-13. | Clinical |
Physical fatigue | Tetsuya Okuyama, et al. Japanese Pharmacology Therapeutics. 2018; 46(8): 1425-1431. | Clinical |
Physical fatigue | Hideki Ohno, et al. Adv Exer Sport Physiol. 2008; 13(4): 93-99. | Clinical |
Mountain climbing, hypoxia | Junichi Nagasawa, et al. Exercise and oxidative stress in hypoxia J Phys Fitness Sports Med. 2013; 2(4): 481-486. | Clinical |
Mountain climbing, hypoxia | Junichi Nagasawa, et al. Oxidative Stress in Hypobaric and Normobaric Hypoxia and Antioxidant Effect of Oligonol Japanese Journal of Mountain Medicine. 2010; 30: 118-124. | Clinical |
Inflammation | Mikio Nishizawa, et al. Phytother Res. 2011; 25(10): 1486-93. | Clinical |
Inflammation | Jeong-Beom Lee, et al. The effect of Oligonol intake on cortisol and related cytokines in healthy young men Nutr Res Pract. 2010; 4(3): 203-7. | Clinical |
Oxidation | Miku Tsukamoto-Kusakabe, et al. Japan Journal of Physical Education, Health and Sport Sciences. 2010; 45: 1-9. | Clinical |
Oxidation | Hideki Ohno, et al. Antioxidant Supplementation in High Altitude Mountaineering: Focusing on Oligonol Japanese Journal of Mountain Medicine. 2007; 27: 43-60. | Clinical |
Blood flow
Cold sensitivity | Hideaki Waki, et al. J Nutr Sci Vitaminol. 2020; 66(3): 255-260. | 臨床 |
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Blood flow | Kentaro Kitadate, et al. Effect of Lychee Fruit Extract (Oligonol) on Peripheral Circulation, a Pilot Study Natural Medicine Journal. 2014; 6(7). | Clinical |
Heat stroke | Jeong Beom Lee, et al. J Med Food. 2015; 18(5): 578-83. | Clinical |
Heat stroke | Jeong Beom Lee, et al. Beneficial effect of Oligonol supplementation on sweating response under heat stress in humans Food Funct. 2014 Oct; 5(10): 2516-20. | Clinical |
Heat stroke | Young Oh Shin, et al. J Med Food. 2013 Apr; 16(4): 318-23. | Clinical |
Heat stroke | Young-Oh Shin, et al. Food Sci Biotechnol. 2011; 20(3): 659-663. | Clinical |
Heat stroke, immunity | Young Oh Shin, et al. The Effect of Oligonol Intake on Leukocytes, Serum HSP70, and Body Temperature after heat stress J.KSLES. 2012; 19(1), 137-145. | Basic |
Ear discomfort | Takeshi Kaneko, et al. Medical Consultation & New Remedies. 2023; 60: 153-164. | Clinical |
Tinnitus | Takahiro Maeda, et al. Japanese Pharmacology Therapeutics. 2016; 44(9): 1329-1336. | Clinical |
Metabolic syndrome and aging
NAFLD | Thananya Jinato, et al. Nutrients. 2022; 14(14): 2921. | Clinical |
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Metabolic syndrome | Suhad M Bahijri, et al. Annu Res Rev Biol. 2017; 16(2). | Clinical |
Metabolic syndrome | Hironobu Uchiyama, et al. Anticancer Res. 2016; 36(7): 3705-13. | Basic |
Obesity, sarcopenia | Jeong Hun Kim, et al. Food Sci Nutr. 2022; 10(4): 1184-1194. | Basic |
Obesity, Hyperlipidemia | Suhad M Bahijri, et al. Curr Nutr Food Sci. 2018; 14(2): 164-170. | Clinical |
Obesity, hyperlipidemia | Jae-Yeo Park, et al. Inhibition of Adipogenesis by Oligonol through Akt-mTOR Inhibition in 3T3-L1 Adipocytes Evid Based Complement Alternat Med. 2014; 2014: 895272. | Basic |
Obesity, hyperlipidemia | Swati Kalgaonkar, et al. Phytother Res. 2010; 24(8): 1223-8. | Basic |
Obesity, hyperlipidemia | Junetsu Ogasawara, et al. Phytother Res. 2009; 23(11): 1626-33. | Basic |
Obesity, hyperlipidemia | Takuya Sakurai, et al. Biosci Biotechnol Biochem. 2008; 72(2): 463-76. | Basic |
Obesity | Kaori Sato, et al. The Journal of Wayo Women’s University. 2021; 62: 33-41. | Basic |
Obesity | Zaure Zhaparkhanova, et al. Use of Oligonol® in Overweight and Obesity Endocrinology Quick Report. 2018; 2(50): 31-34. | Basic |
Obesity | Masaki Taga, et al. Clinical Pharmacology and Therapy. 2016; 26(3): 85-96. | Clinical |
Obesity | Jun Nishihira, et al. Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee J Funct Foods. 2009; 1(4): 341-348. | Clinical |
Diabetes | Chan Hum Park, et al. Phytother Res. 2018; 32(12): 2541-2550. | Basic |
Diabetes | Himanshu Kumar Bhakta, et al. Arch Pharm Res. 2017; 40(11): 1314-1327. | Basic |
Diabetes, pancreatic protection | Chan Hum Park, et al. Food Funct. 2016; 7(7): 3056-3063. | Basic |
Diabetes, hepatic protection | Jeong Sook Noh, et al. Br J Nutr. 2011; 106(7): 1013-22. | Basic |
Diabetes, renal protection | Hung-Wen Liu, et al. Food Funct. 2016; 7(4): 1941-9. | Basic |
Diabetes, renal protection | Chan Hum Park, et al. Drug Discov Ther. 2015; 9(1): 13-22. | Basic |
Diabetes, renal protection | Chan Hum Park, et al. J Nutr. 2014; 144(8): 1150-7. | Basic |
Diabetes, renal protection | Jeong Sook Noh, et al. Br J Nutr. 2010; 104(8): 1120-8. | Basic |
Diabetes, sarcopenia | Hung-Wen Liu, et al. Nutrients. 2017; 9(9): 1040. | Basic |
Diabetes, hyperlipidemia | Jun Takanari, et al. Clin Pharmacol Ther. 2017; 27(4): 195-205. | Basic |
Diabetes, hyperlipidemia, sarcopenia | Hung-Wen Liu, et al. Mol Nutr Food Res. 2016; 60(10): 2288-2296. | Basic |
Diabetes, Alzheimer’s disease | Jae Sue Choi, et al. Arch Pharm Res. 2016; 39(3): 409-420. | Basic |
Diabetes, vascular endothelial function | Xiao-Hong Zhang, et al. Br J Pharmacol. 2010; 159(4): 928-38. | Basic |
Obesity, hyperlipidemia, diabetes | Koji Wakame Functions of low molecular weight polyphenols from lychee fruit FOOD STYLE 21. 2007; 125: 65. | Review |
Hyperlipidemia | Khota Hayashi, et al. J Oleo Sci. 2020; 69(9): 1077-1085. | Basic |
Hyperlipidemia | Jae-Yeo Park, et al. BMC Complement Altern Med. 2015; 15: 185. | Basic |
Hyperlipidemia | Junetsu Ogasawara, et al. Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery Nat Prod Commun. 2012; 7(9): 1193-6. | Basic |
Hyperlipidemia | Junetsu Ogasawara, et al. Phytother Res. 2011; 25(3): 467-71. | Basic |
Hyperlipidemia | Junetsu Ogasawara, et al. Biochem Biophys Res Commun. 2010; 402(3): 554-9. | Basic |
Hyperlipidemia, thrombus | Ryu Miyagawa, et al. The effect of insulin on the production of plasminogen activator inhibitor type-1 in HepG2 cells Heart. 2010; 42(9): 1153-1158. | Basic |
Gout | Yuji Moriwaki, et al. J Funct Foods. 2011; 3(1): 13-16. | Clinical |
Hair loss | Koji Wakame, et al. J Biomed Transl Res. 2017; 1, 6-12. | Basic |
Sirtuin, autophagy | Seul-Ki Park, et al. Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway Nutr Res Pract. 2016; 10(1): 3-10. | Basic |
Beauty
Skin protection | Joydeb Kumar Kundu, et al. J Funct Foods. 2009; 1(1): 98-108. | Basic |
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Skin protection | Koji Wakame, et al. Antibacterial and beautiful skin effects of low molecular weight polyphenols Fragrance journal. 2009; 37(11): 65-68. | Clinical |
Review
Physical fatigue | Takuma Shio, et al. Sports nutrition: anti-fatigue effects of Oligonol®. FOOD STYLE 21. 2021; 25(5): 52-56. | Review |
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Physical fatigue | Jun Takanari, et al. FOOD STYLE 21. 2014; 209: 71-74. | Review |
Obesity, hyperlipidemia | Takuya Sakurai, et al. Antioxidant effects of a novel low molecular weight polyphenol, Oligonol FOOD FUNCTION. 2009; 5(1): 2-7. | Review |
Obesity | Asuka Yasueda, et al. Review: Evidence-based Clinical Research of Anti-obesity Supplements in Japan Immunol Endocr Metab Agents Med Chem. 2013; 13(3): 185-195. | Review |
Pet animal | Mamoru Onuma, et al. The supplementation therapy of caine dermatology in my hospital Japanese Journal of Small Animal Practice. 2008; 27(6): 340-346. | Veterinary |
Manufacturing | Takashi Tanaka, et al. Production of oligomeric proanthocyanidins by fragmentation of polymers Japanese Journal of Food Chemistry. 2007; 14(3): 134-139. | Basic |
Robert Fried, et al. Multiple Protective Functions of Oligonol from Lychee Type 2 Diabetes: Cardiovascular and Related Complications and Evidence-based Complementary Treatments (CHES). 2020: 269-273. | Book | |
Yousef A Al-Dashti, et al. J Am Coll Nutr. 2018; 37(7): 553-567. | Review | |
Kazumi Hayama, et al. Health-promoting effects of a oligomerized polyphenol, oligonol on the athleates and elderly people Bulletin of Sports and Medical Science. 2014; 6: 17-21. | Review | |
Jun Takanari, et al. Functions of a new generation of low molecular weight polyphenols (Oligonol) New Food Industry. 2011; 53(3): 9-21. | Review | |
Koji Wakame, et al. Functions of a new generation of low molecular weight polyphenols (Oligonol) aromatopia. 2011; 20(4): 87-91. | Review | |
Takehito Miura, et al. The Function of the Next Generation Polyphenol, “Oligonol” Biotechnology in Functional Foods and Nutraceuticals. 2010: 91-101. | Book | |
Takehito Miura, et al. Functions of Oligonol, a New Generation Polyphenol Japan Food Science. 2010; 49(1): 37-44. | Review | |
Takehito Miura, et al. The Function of the Next Generation of Polyphenol “Oligonol” Japanese Journal of Complementary and Alternative Medicine. 2008; 5(3): 163-171. | Review |
Other
Psychological stress | Akihiro Ishida, et al. Bull Tokyo Dent Coll. 2023. | Clinical |
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Sarcopenia | Li-Ning Peng, et al. Arch Gerontol Geriatr. 2022; 103: 104784. | Clinical |
Sarcopenia | Yun-Ching Chang, et al. Mol Nutr Food Res. 2019; 63(10): e1801102. | Basic |
Opportunistic infection, Candida | Mie Kojima, et al. Usefulness of Aroma Candy in the Oral Care of Residents of Special Elderly Nursing Homes The Japanese Journal of Dysphagia Rehabilitation. 2021; 25(2): 120-128 | Clinical |
Opportunistic infection, Candida | Yoichi Nakagawa, et al. Oral Therapeutics and Pharmacology. 2018; 37(3): 101-107. | Clinical |
Opportunistic infection, Candida | Kazumi Hayama, et al. Drug Discov Ther. 2015; 9(6): 386-90. | Basic |
Opportunistic infection, Candida | Kazumi Hayama, et al. Development of a new aroma candy for maintenance of the oral health Med Mycol Res. 2015; 6(1): 3-9. | Clinical |
Opportunistic infection, Candida | Motofumi Suzuki, et al. Medical Mycology Journal. 2015; 56: J31-J40. | Clinical |
Opportunistic infection, Candida | Kazumi Hayama, et al. Anti-Candida Activity of Aroma Candy and Its Protective Activity Against Murine Oral Candidiasis Medical Mycology Journal. 2015; 56: J23-J29. | Basic |
Opportunistic infection, Candida | Kazumi Hayama, et al. Japanese Journal of Medical Mycology. 2010; 51(3): 137–142. | Basic |
Betanodavirus | Toru Ichinose, et al. Evaluation of antiviral activity of Oligonol, an extract of Litchi chinensis, against betanodavirus Drug Discov Ther. 2013; 7(6): 254-60. | Basic |
Influenza | Noboru Uchide, et al. Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications Molecules. 2011; 16(3): 2032-52. | Basic |
Influenza | Leila Gangehei, et al. Phytomedicine. 2010; 17(13): 1047-56. | Basic |
Dry mouth | Jeong Hun Kim, et al. Effects of oligonol on the submandibular gland in ovariectomized rats Biomed Pharmacother. 2021;141:111897. | Basic |
Retinal protecion | Jun Kisugi, et al. ABC. 2014; 4(2), 138-147. | Basic |
Liver fibrosis | Jihyun Kim, et al. Antioxidants. 2023; 12(8): 1588. | Basic |
Liver fibrosis | Changyong Lee, et al. Antioxidants. 2021; 10(3): 366. | Basic |
Immunity | Jeong Beom Lee, et al. Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans Nutrients. 2014; 6(6): 2466-77. | Clinical |
Colitis | K-J Kim, et al. J Physiol Pharmacol. 2018; 69(3). | Basic |
Colitis | Hye-Won Yum, et al. Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice Antioxid Redox Signal. 2013; 19(2): 102-14. | Basic |
Prostatitis | İlhan Öztekin, et al. Evid Based Complement Alternat Med. 2015; 2015: 687196. | Basic |
Prostatitis | Hakan Akdere, et al. Iran Red Crescent Med J. 2015; 17(4): e26006. | Basic |
Hepatitis | Jeonghyeon Bak, et al. Oxid Med Cell Longev. 2016; 2016: 3935841. | Basic |
Esophagitis, gastric ulcer | Seong-Soo Roh, et al. J Med Food. 2017; 20(12): 1214-1221. | Basic |
Air pollution | Takumi Shibukawa, et al. Absorption of Nitrogen Dioxide by the Polyphenol Solution Kagaku kogaku ronbunshu. 2011; 37(2): 162-166. | Basic |
Sexual performance | Koji Wakame, et al. Attempt to develop a sexual function-improving drink containing various natural food ingredients FOOD STYLE 21. 2011; 165: 41-43. | Clinical |
Neurodegenerative disease | Jae Hyun Ahn, et al. Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell Nutr Res Pract. 2015; 9(2): 123-8. | Basic |
Anti-oxidation | Katsuhiko Suzuki, et al. Functional Analyses of Oligonol by Novel Neutrophil Activity Measurement System Japanese Journal of Complementary and Alternative Medicine. 2013; 10(1): 59-62. | Basic |
Anti-inflammation | Naeun Lee, et al. Hum Immunol. 2016; 77(6): 512-5. | Basic |
Supercooling | Tsutomu Uchida, et al. Effect of Polyphenols on the Ice-Nucleation Activity of Ultrafine Bubbles Nanomaterials. 2023; 13(1): 205. | Basic |
Supercooling | Seizo Fujikawa, et al. Supercooling-Promoting (Anti-ice Nucleation) Substances Survival Strategies in Extreme Cold and Desiccation. 2018: 289-320. | Book |
Supercooling | Seizo Fujikawa, et al. Current Research on Supercooling Accelerators Functions and Applications of Antifreeze Protein. 2018: 180-190. | Book |
Supercooling | Toshie Koyama, et al. Anti-ice nucleating activity of polyphenol compounds against silver iodide Cryobiology. 2014; 69(2): 223-8. | Basic |
Supercooling | Chikako Kuwabara, et al. Analysis of supercooling activity of tannin-related polyphenols Cryobiology. 2013; 67(1): 40-9. | Review |
Alzheimer’s disease | Xiao Chen, et al. Nutr Neurosci. 2019; 1-15. | Basic |
Alzheimer’s disease | Yoon Young Choi, et al. Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer’s mouse model Nutr Res. 2014; 34(7): 595-603. | Basic |
Cognitive function | Takuya Sakurai, et al. Br J Nutr. 2013; 110(9): 1549-58. | Basic |
Ovarian cancer | Miseon Kim, et al. Nutr Cancer. 2019; 71(1): 141-148. | Basic |
Malignant melanoma, lung metastasis | Sung-Jae Lee, et al. Inhibition of Lung Metastasis in Mice by Oligonol Phytother Res. 2009; 23(7): 1043-6. | Basic |
Action mechanism | Ryota Yamanishi, et al. The Anti-inflammatory Effects of Flavanol-rich Lychee Fruit Extract in Rat Hepatocytes PLoS One. 2014; 9(4): e93818. | Basic |
Safety | Kentaro Kitadate, et al. Regul Toxicol Pharmacol. 2014; 68(1): 140-6. | Basic |
Safety | Mahesh Thirunavukkarasu, et al. Toxicol Mech Methods. 2012; 22(7): 555-9. | Basic |
Safety | Hajime Fujii, et al. Food Chem Toxicol. 2008; 46(12): 3553-62. | Basic |