Oligonol®Study Results

Scientific Publications

.List of Scientific Publications

To date, universities and research institutes around the world have been engaged in research on Oligonol®, and more than 100 papers have been published.

Exercise and sport

Exercise performance

Aki Kawamura, et al.

Oligomerized polyphenols in lychee fruit extract supplements may improve high-intensity exercise performance in male athletes: a pilot study

Phys Act Nutr. 2021; 25(3): 8-15.

Clinical
Exercise performance

Seung Wan Kang, et al.

Oligomerized lychee fruit extract (OLFE) and a mixture of vitamin C and vitamin E for endurance capacity in a double blind randomized controlled trial

J Clin Biochem Nutr. 2012; 50(2): 106-13.

Clinical
Physical fatigue

Tetsuya Okuyama, et al.

The Ameliorative Effect of the Oligomerized-polyphenol from Litchi chinensis Fruit Extract (OPLFE) on Temporary Physical Fatigue for University Track and Field Athletes -The Second Report Focused on the Subjective Assessments-

Japanese Pharmacology Therapeutics. 2018; 46(8): 1425-1431.

Clinical
Physical fatigue

Hideki Ohno, et al.

The Supplementation of Oligonol, the New Lychee Fruit-derived Polyphenol Converting into a Low-molecular Form, Has a Positive Effect on Fatigue during Regular Track-and-field Training in Young Athletes

Adv Exer Sport Physiol. 2008; 13(4): 93-99.

Clinical
Mountain climbing, hypoxia

Junichi Nagasawa, et al.

Exercise and oxidative stress in hypoxia

J Phys Fitness Sports Med. 2013; 2(4): 481-486.

Clinical
Mountain climbing, hypoxia

Junichi Nagasawa, et al.

Oxidative Stress in Hypobaric and Normobaric Hypoxia and Antioxidant Effect of Oligonol

Japanese Journal of Mountain Medicine. 2010; 30: 118-124.

Clinical
Inflammation

Mikio Nishizawa, et al.

Supplementation with a Flavanol-rich Lychee Fruit Extract Influences the Inflammatory Status of Young Athletes

Phytother Res. 2011; 25(10): 1486-93.

Clinical
Inflammation

Jeong-Beom Lee, et al.

The effect of Oligonol intake on cortisol and related cytokines in healthy young men

Nutr Res Pract. 2010; 4(3): 203-7.

Clinical
Oxidation

Miku Tsukamoto-Kusakabe, et al.

Effect of polyphenol converting into a low-molecular form on oxidative stress and serum total antioxidative capacity in high-intensity intermittent spring exercise

Japan Journal of Physical Education, Health and Sport Sciences. 2010; 45: 1-9.

Clinical
Oxidation

Hideki Ohno, et al.

Antioxidant Supplementation in High Altitude Mountaineering: Focusing on Oligonol

Japanese Journal of Mountain Medicine. 2007; 27: 43-60.

Clinical
Sarcopenia

Yun-Ching Chang, et al.

Oligonol®, an Oligomerized Polyphenol from Litchi chinensis, Enhances Branched-Chain Amino Acid Transportation and Catabolism to Alleviate Sarcopenia

Int J Mol Sci. 2024; 25(21): 115494.

Basic
Sarcopenia

Li-Ning Peng, et al.

Clinical efficacy of oligonol® supplementation on metabolism and muscle health in middle-aged and older adults: A double-blinded randomized controlled trial

Arch Gerontol Geriatr. 2022; 103: 104784.

Clinical
Sarcopenia

Yun-Ching Chang, et al.

Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality

Mol Nutr Food Res. 2019; 63(10): e1801102.

Basic

Blood flow

Cold sensitivity

Hideaki Waki, et al.

Effects of a Standardized Oligomerized-Polyphenol from Litchi chinensis Fruit Extract and Mixed Plant Extract Supplementation on Peripheral Circulation and Cold Sensitivity

J Nutr Sci Vitaminol. 2020; 66(3): 255-260.

Clinical
Blood flow

Kentaro Kitadate, et al.

Effect of Lychee Fruit Extract (Oligonol) on Peripheral Circulation, a Pilot Study

Natural Medicine Journal. 2014; 6(7).

Clinical
Heat stroke

Jennifer S Peel, et al.

The effect of dietary supplements on core temperature and sweating responses in hot environmental conditions: a meta-analysis and meta-regression

Am J Physiol Regul Integr Comp Physiol. 2025; 328(4): R515-R555.

Review
Heat stroke

Jeong Beom Lee, et al.

Oligonol Supplementation Modulates Plasma Volume and Osmolality and Sweating After Heat Load in Humans

J Med Food. 2015; 18(5): 578-83.

Clinical
Heat stroke

Jeong Beom Lee, et al.

Beneficial effect of Oligonol supplementation on sweating response under heat stress in humans

Food Funct. 2014 Oct; 5(10): 2516-20.

Clinical
Heat stroke

Young Oh Shin, et al.

Oligonol Supplementation Attenuates Body Temperature and the Circulating Levels of Prostaglandin E2 and Cyclooxygenase-2 After Heat Stress in Humans

J Med Food. 2013 Apr; 16(4): 318-23.

Clinical
Heat stroke

Young-Oh Shin, et al.

Effect of Oligonol Intake on Cortisol and Cytokines, and Body Temperature after Leg Immersion into Hot Water

Food Sci Biotechnol. 2011; 20(3): 659-663.

Clinical
Heat stroke, immunity

Young Oh Shin, et al.

The Effect of Oligonol Intake on Leukocytes, Serum HSP70, and Body Temperature after heat stress

J.KSLES. 2012; 19(1), 137-145.

Basic
Ear discomfort

Takeshi Kaneko, et al.

Evaluation of the effects of the food containing Ginkgo biloba extract and low-molecular-weight lychee polyphenols on the improvement of ear discomfort in normal subjects: a randomized, double-blind, placebo-controlled, parallel-group comparative study

Medical Consultation & New Remedies. 2023; 60: 153-164.

Clinical
Tinnitus

Takahiro Maeda, et al.

Investigation of the Amelioration Effects of Oligonol® on Tinnitus in Randomized Double-blinded Placebo-controlled Trial

Japanese Pharmacology Therapeutics. 2016; 44(9): 1329-1336.

Clinical

Metabolic syndrome and aging

NAFLD

Thananya Jinato, et al.

Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study

Nutrients. 2022; 14(14): 2921.

Clinical
Metabolic syndrome

Suhad M Bahijri, et al.

Oligonol Supplementation Decreases Cardiometabolic Risk Factors, and the Prevalence of Metabolic Syndrome in a Sample of Overweight and Obese Saudi Females

Annu Res Rev Biol. 2017; 16(2).

Clinical
Metabolic syndrome

Hironobu Uchiyama, et al.

Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®)

Anticancer Res. 2016; 36(7): 3705-13.

Basic
Obesity, sarcopenia

Jeong Hun Kim, et al.

Effect of oligonol, a lychee-derived polyphenol, on skeletal muscle in ovariectomized rats by regulating body composition, protein turnover, and mitochondrial quality signaling

Food Sci Nutr. 2022; 10(4): 1184-1194.

Basic
Obesity, Hyperlipidemia

Suhad M Bahijri, et al.

Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females

Curr Nutr Food Sci. 2018; 14(2): 164-170.

Clinical
Obesity, hyperlipidemia

Jae-Yeo Park, et al.

Inhibition of Adipogenesis by Oligonol through Akt-mTOR Inhibition in 3T3-L1 Adipocytes

Evid Based Complement Alternat Med. 2014; 2014: 895272.

Basic
Obesity, hyperlipidemia

Swati Kalgaonkar, et al.

Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and induces of metabolic syndrome in animal models

Phytother Res. 2010; 24(8): 1223-8.

Basic
Obesity, hyperlipidemia

Junetsu Ogasawara, et al.

Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway

Phytother Res. 2009; 23(11): 1626-33.

Basic
Obesity, hyperlipidemia

Takuya Sakurai, et al.

Antioxidative effects of a new lychee fruit derived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes

Biosci Biotechnol Biochem. 2008; 72(2): 463-76.

Basic
Obesity

Jun Takanari, et al.

Effects of Oligonol® supplementation on abdominal fat in Japanese overweight volunteers: a randomized, double-blind, placebo-controlled, parallel group study

J Nutr Sci Vitaminol. 2025.

Clinical
Obesity

Kaori Sato, et al.

Effect of a standardized oligomerized-polyphenol from Litchi chinensis fruit extract “Oligonol®” on against postmenopausal obesity in ovariectomized rats

The Journal of Wayo Women’s University. 2021; 62: 33-41.

Basic
Obesity

Zaure Zhaparkhanova, et al.

Use of Oligonol® in Overweight and Obesity

Endocrinology Quick Report. 2018; 2(50): 31-34.

Basic
Obesity

Masaki Taga, et al.

Anti-obesity effects of Oligonol in healthy subjects: a double blind, randomized placebo-controlled trial

Clinical Pharmacology and Therapy. 2016; 26(3): 85-96.

Clinical
Obesity

Jun Nishihira, et al.

Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee

J Funct Foods. 2009; 1(4): 341-348.

Clinical
Diabetes

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee peel, attenuates diabetes-induced pancreatic damage by inhibiting inflammatory responses via oxidative stress-dependent mitogen-activated protein kinase/nuclear factor-kappa B signaling

Phytother Res. 2018; 32(12): 2541-2550.

Basic
Diabetes

Himanshu Kumar Bhakta, et al.

Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B

Arch Pharm Res. 2017; 40(11): 1314-1327.

Basic
Diabetes, pancreatic protection

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats

Food Funct. 2016; 7(7): 3056-3063.

Basic
Diabetes, hepatic protection

Jeong Sook Noh, et al.

Treatment with Oligonol, a low-molecular Polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

Br J Nutr. 2011; 106(7): 1013-22.

Basic
Diabetes, renal protection

Hung-Wen Liu, et al.

Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice

Food Funct. 2016; 7(4): 1941-9.

Basic
Diabetes, renal protection

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity mediated renal disorder in type 2 diabetic db/db mice

Drug Discov Ther. 2015; 9(1): 13-22.

Basic
Diabetes, renal protection

Chan Hum Park, et al.

Oligonol, a Low-Molecular-Weight Polyphenol Derived from Lychee Fruit, Attenuates Diabetes-Induced Renal Damage through the Advanced Glycation End Product–Related Pathway in db/db Mice

J Nutr. 2014; 144(8): 1150-7.

Basic
Diabetes, renal protection

Jeong Sook Noh, et al.

Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice.

Br J Nutr. 2010; 104(8): 1120-8.

Basic
Diabetes, sarcopenia

Hung-Wen Liu, et al.

Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1

Nutrients. 2017; 9(9): 1040.

Basic
Diabetes, hyperlipidemia

Jun Takanari, et al.

Oligonol, a low molecular weight polyphenol of lychee fruit extract, suppresses absorption of glucose and fat

Clin Pharmacol Ther. 2017; 27(4): 195-205.

Basic
Diabetes, hyperlipidemia, sarcopenia

Hung-Wen Liu, et al.

Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle

Mol Nutr Food Res. 2016; 60(10): 2288-2296.

Basic
Diabetes, Alzheimer’s disease

Jae Sue Choi, et al.

Inhibitory evaluation of oligonol on α-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and β-secretase 1 related to diabetes and Alzheimer’s disease

Arch Pharm Res. 2016; 39(3): 409-420.

Basic
Diabetes, vascular endothelial function

Xiao-Hong Zhang, et al.

Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

Br J Pharmacol. 2010; 159(4): 928-38.

Basic
Obesity, hyperlipidemia, diabetes

Koji Wakame

Functions of low molecular weight polyphenols from lychee fruit

FOOD STYLE 21. 2007; 125: 65.

Review
Hyperlipidemia

Khota Hayashi, et al.

Oligonol, a Low-molecular Weight Polyphenol Extracted from Lychee Fruit, Modulates Cholesterol Metabolism in Rats within a Short Period

J Oleo Sci. 2020; 69(9): 1077-1085.

Basic
Hyperlipidemia

Jae-Yeo Park, et al.

Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model

BMC Complement Altern Med. 2015; 15: 185.

Basic
Hyperlipidemia

Junetsu Ogasawara, et al.

Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery

Nat Prod Commun. 2012; 7(9): 1193-6.

Basic
Hyperlipidemia

Junetsu Ogasawara, et al.

Comparison of the Effect of Oligonol, A New Lychee Fruit-derived Low Molecular Form of Polyphenol, and Epigallocatechin-3-gallate on Lipolysis in Rat Primary Adipocytes

Phytother Res. 2011; 25(3): 467-71.

Basic
Hyperlipidemia

Junetsu Ogasawara, et al.

Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/ Raf-1/ MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes

Biochem Biophys Res Commun. 2010; 402(3): 554-9.

Basic
Hyperlipidemia, thrombus

Ryu Miyagawa, et al.

The effect of insulin on the production of plasminogen activator inhibitor type-1 in HepG2 cells

Heart. 2010; 42(9): 1153-1158.

Basic
Gout

Yuji Moriwaki, et al.

Effects of Oligonol®, an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid

J Funct Foods. 2011; 3(1): 13-16.

Clinical
Hair loss

Koji Wakame, et al.

Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells

J Biomed Transl Res. 2017; 1, 6-12.

Basic
Sirtuin, autophagy

Seul-Ki Park, et al.

Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway

Nutr Res Pract. 2016; 10(1): 3-10.

Basic

Beauty

Skin protection

Joydeb Kumar Kundu, et al.

Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin

J Funct Foods. 2009; 1(1): 98-108.

Basic
Skin protection

Koji Wakame, et al.

Antibacterial and beautiful skin effects of low molecular weight polyphenols

Fragrance journal. 2009; 37(11): 65-68.

Clinical

Review

Physical fatigue

Takuma Shio, et al.

Sports nutrition: anti-fatigue effects of Oligonol®.

FOOD STYLE 21. 2021; 25(5): 52-56.

Review
Physical fatigue

Jun Takanari, et al.

Anti-fatigue effects of Oligonol, a low-molecular-weight polyphenol, a “next-generation sports nutrition

FOOD STYLE 21. 2014; 209: 71-74.

Review
Obesity, hyperlipidemia

Takuya Sakurai, et al.

Antioxidant effects of a novel low molecular weight polyphenol, Oligonol

FOOD FUNCTION. 2009; 5(1): 2-7.

Review
Obesity

Asuka Yasueda, et al.

Review: Evidence-based Clinical Research of Anti-obesity Supplements in Japan

Immunol Endocr Metab Agents Med Chem. 2013; 13(3): 185-195.

Review
Pet animal

Mamoru Onuma, et al.

The supplementation therapy of caine dermatology in my hospital

Japanese Journal of Small Animal Practice. 2008; 27(6): 340-346.

Veterinary
Manufacturing

Takashi Tanaka, et al.

Production of oligomeric proanthocyanidins by fragmentation of polymers

Japanese Journal of Food Chemistry. 2007; 14(3): 134-139.

Basic

Robert Fried, et al.

Multiple Protective Functions of Oligonol from Lychee

Type 2 Diabetes: Cardiovascular and Related Complications and Evidence-based Complementary Treatments (CHES). 2020: 269-273.

Book

Yousef A Al-Dashti, et al.

Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance

J Am Coll Nutr. 2018; 37(7): 553-567.

Review

Kazumi Hayama, et al.

Health-promoting effects of a oligomerized polyphenol, oligonol on the athleates and elderly people

Bulletin of Sports and Medical Science. 2014; 6: 17-21.

Review

Jun Takanari, et al.

Functions of a new generation of low molecular weight polyphenols (Oligonol)

New Food Industry. 2011; 53(3): 9-21.

Review

Koji Wakame, et al.

Functions of a new generation of low molecular weight polyphenols (Oligonol)

aromatopia. 2011; 20(4): 87-91.

Review

Takehito Miura, et al.

The Function of the Next Generation Polyphenol, “Oligonol”

Biotechnology in Functional Foods and Nutraceuticals. 2010: 91-101.

Book

Takehito Miura, et al.

Functions of Oligonol, a New Generation Polyphenol

Japan Food Science. 2010; 49(1): 37-44.

Review

Takehito Miura, et al.

The Function of the Next Generation of Polyphenol “Oligonol”

Japanese Journal of Complementary and Alternative Medicine. 2008; 5(3): 163-171.

Review

Other

Psychological stress

Akihiro Ishida, et al.

Influence of Chewing Gummy Jelly Containing Aroma Compound on Psychological Stress and Autonomic Nervous System Activity: A Randomized Crossover Trial

Bull Tokyo Dent Coll. 2023.

Clinical
Opportunistic infection, Candida

Tetsuji Azuma, et al.

Effects of Chewing Gum Containing Modified DOMAC® on Tongue Hygiene and Psychological Factors ─A Placebo-controlled, Double-blind, Parallel-group Study─

J Dent Hlth. 2024; 74(4): 265-273

Clinical
Opportunistic infection, Candida

Mie Kojima, et al.

Usefulness of Aroma Candy in the Oral Care of Residents of Special Elderly Nursing Homes

The Japanese Journal of Dysphagia Rehabilitation. 2021; 25(2): 120-128

Clinical
Opportunistic infection, Candida

Yoichi Nakagawa, et al.

Anti-Candida effectiveness of a candy containing citral, cinnamaldehyde, oligonol, and capric acid for oral candidiasis

Oral Therapeutics and Pharmacology. 2018; 37(3): 101-107.

Clinical
Opportunistic infection, Candida

Kazumi Hayama, et al.

Development of a new aroma candy for maintenance of the oral health

Med Mycol Res. 2015; 6(1): 3-9.

Clinical
Opportunistic infection, Candida

Motofumi Suzuki, et al.

The Effects of an Aroma Candy on Oral Candida albicans Colony-forming Units (CFU) and Oral Hygiene States in Healthy Elderly Carrying Candida albicans

Medical Mycology Journal. 2015; 56: J31-J40.

Clinical
Opportunistic infection, Candida

Kazumi Hayama, et al.

Anti-Candida Activity of Aroma Candy and Its Protective Activity Against Murine Oral Candidiasis

Medical Mycology Journal. 2015; 56: J23-J29.

Basic
Opportunistic infection, Candida

Kazumi Hayama, et al.

Inhibitory effects of several saturated fatty acids and their related fatty alcohols on the growth of Candida albicans

Drug Discov Ther. 2015; 9(6): 386-90.

Basic
Opportunistic infection, Candida

Kazumi Hayama, et al.

Therapeutic Effect of Oligonol, a Low-molecular Polyphenol Formulation Derived from Lychee Fruits on Murine Oral Candidiasis

Japanese Journal of Medical Mycology. 2010; 51(3): 137–142.

Basic
Betanodavirus

Toru Ichinose, et al.

Evaluation of antiviral activity of Oligonol, an extract of Litchi chinensis, against betanodavirus

Drug Discov Ther. 2013; 7(6): 254-60.

Basic
Influenza

Noboru Uchide, et al.

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Molecules. 2011; 16(3): 2032-52.

Review
Influenza

Leila Gangehei, et al.

Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation

Phytomedicine. 2010; 17(13): 1047-56.

Basic
Dry mouth

Jeong Hun Kim, et al.

Effects of oligonol on the submandibular gland in ovariectomized rats

Biomed Pharmacother. 2021;141:111897.

Basic
Retinal protecion

Jun Kisugi, et al.

Suppression of N-Methyl-N-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

ABC. 2014; 4(2), 138-147.

Basic
Liver fibrosis

Jihyun Kim, et al.

Integrative Transcriptomic Analysis Reveals Upregulated Apoptotic Signaling in Wound-Healing Pathway in Rat Liver Fibrosis Models

Antioxidants. 2023; 12(8): 1588.

Basic
Liver fibrosis

Changyong Lee, et al.

Protective Effect of Oligonol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats via the JNK/NF-κB and PI3K/Akt/Nrf2 Signaling Pathways

Antioxidants. 2021; 10(3): 366.

Basic
Immunity

Jeong Beom Lee, et al.

Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans

Nutrients. 2014; 6(6): 2466-77.

Clinical
Colitis

K-J Kim, et al.

Oligonol prevented the relapse of dextran sulfate sodium-ulcerative colitis through enhancing NRF2-mediated antioxidative defense mechanism

J Physiol Pharmacol. 2018; 69(3).

Basic
Colitis

Hye-Won Yum, et al.

Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice

Antioxid Redox Signal. 2013; 19(2): 102-14.

Basic
Prostatitis

İlhan Öztekin, et al.

Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis

Evid Based Complement Alternat Med. 2015; 687196.

Basic
Prostatitis

Hakan Akdere, et al.

Analgesic Effects of Oligonol, Acupuncture and Quantum Light Therapy on Chronic Nonbacterial Prostatitis

Iran Red Crescent Med J. 2015; 17(4): e26006.

Basic
Hepatitis

Jeonghyeon Bak, et al.

Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NK-Kappa B and MAPK Signaling Pathways

Oxid Med Cell Longev. 2016; 3935841.

Basic
Esophagitis, gastric ulcer

Seong-Soo Roh, et al.

Low-Molecular-Weight Oligonol, a Polyphenol Derived from Lychee Fruit, Attenuates Experimental Reflux Esophagitis and HCl/Ethanol-Induced Gastric Ulcer

J Med Food. 2017; 20(12): 1214-1221.

Basic
Air pollution

Takumi Shibukawa, et al.

Absorption of Nitrogen Dioxide by the Polyphenol Solution

Kagaku kogaku ronbunshu. 2011; 37(2): 162-166.

Basic
Sexual performance

Koji Wakame, et al.

Attempt to develop a sexual function-improving drink containing various natural food ingredients

FOOD STYLE 21. 2011; 165: 41-43.

Clinical
Neurodegenerative disease

Jae Hyun Ahn, et al.

Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell

Nutr Res Pract. 2015; 9(2): 123-8.

Basic
Anti-oxidation

Katsuhiko Suzuki, et al.

Functional Analyses of Oligonol by Novel Neutrophil Activity Measurement System

Japanese Journal of Complementary and Alternative Medicine. 2013; 10(1): 59-62.

Basic
Anti-inflammation

Naeun Lee, et al.

Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes

Hum Immunol. 2016; 77(6): 512-5.

Basic
Supercooling

Tsutomu Uchida, et al.

Effect of Polyphenols on the Ice-Nucleation Activity of Ultrafine Bubbles

Nanomaterials. 2023; 13(1): 205.

Basic
Supercooling

Seizo Fujikawa, et al.

Current Research on Supercooling Accelerators

Functions and Applications of Antifreeze Protein. 2018: 180-190.

Book
Supercooling

Seizo Fujikawa, et al.

Supercooling-Promoting (Anti-ice Nucleation) Substances

Survival Strategies in Extreme Cold and Desiccation. 2018: 289-320.

Book
Supercooling

Toshie Koyama, et al.

Anti-ice nucleating activity of polyphenol compounds against silver iodide

Cryobiology. 2014; 69(2): 223-8.

Basic
Supercooling

Chikako Kuwabara, et al.

Analysis of supercooling activity of tannin-related polyphenols

Cryobiology. 2013; 67(1): 40-9.

Review
Alzheimer’s disease

Danbi Jo, et al.

Oligonol ameliorates liver function and brain function in the 5 × FAD mouse model: transcriptional and cellular analysis

Food Funct. 2023; 14(21): 9650-9670.

Basic
Alzheimer’s disease

Xiao Chen, et al.

Flavanol-rich lychee fruit extract substantially reduces progressive cognitive and molecular deficits in a triple-transgenic animal model of Alzheimer disease

Nutr Neurosci. 2019; 1-15.

Basic
Alzheimer’s disease

Yoon Young Choi, et al.

Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer’s mouse model

Nutr Res. 2014; 34(7): 595-603.

Basic
Cognitive function

Seo Yoon Choi, et al.

Oligonol enhances brain cognitive function in high-fat diet-fed mice

Biomed Pharmacother. 2024; 179: 117322.

Basic
Cognitive function

Takuya Sakurai, et al.

Oligomerized lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells

Br J Nutr. 2013; 110(9): 1549-58.

Basic
Chemotherapy

Yun-Ching Chang, et al.

Low-molecular-weight polyphenol promotes cell sensitivity to cisplatin and alleviates cancer-related muscle atrophy via NF-κB suppression in oral squamous cell carcinoma

J Oral Biosci. 2025; 67(1): 100595.

Basic
Nasopharyngeal cancer

Yen-Ting Wu, et al.

Treatment with autophagic inhibitors enhances oligonol‑induced apoptotic effects in nasopharyngeal carcinoma cells

Biomed Rep. 2024; 21(4): 143.

Basic
Ovarian cancer

Miseon Kim, et al.

Oligonol, a Low Molecular Weight Polyphenol, Enhances Apoptotic Cell Death in Ovarian Cancer Cells via Suppressing NF-κB Activation

Nutr Cancer. 2019; 71(1): 141-148.

Basic
Malignant melanoma, lung metastasis

Sung-Jae Lee, et al.

Inhibition of Lung Metastasis in Mice by Oligonol

Phytother Res. 2009; 23(7): 1043-6.

Basic
Action mechanism

Ryota Yamanishi, et al.

The Anti-inflammatory Effects of Flavanol-rich Lychee Fruit Extract in Rat Hepatocytes

PLoS One. 2014; 9(4): e93818.

Basic
Safety

Kentaro Kitadate, et al.

Thirteen-week oral dose toxicity study of Oligonol containing oligomerized polyphenols extracted from lychee and green tea

Regul Toxicol Pharmacol. 2014; 68(1): 140-6.

Basic
Safety

Mahesh Thirunavukkarasu, et al.

Safety of oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on liver, kidney and heart function in rats

Toxicol Mech Methods. 2012; 22(7): 555-9.

Basic
Safety

Hajime Fujii, et al.

Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts

Food Chem Toxicol. 2008; 46(12): 3553-62.

Basic