Scientific Publications

Masaaki Sugita, et al.

Oligomerized polyphenols in lychee fruit extract supplements may improve high-intensity exercise performance in male athletes: a pilot study

Physical Activity and Nutrition 2021;25(3):8-15.

Seung Wan Kang, et al.

Oligomerized lychee fruit extract (OLFE) and a mixture of vitamin C and vitamin E for endurance capacity in a double blind randomized controlled trial

J Clin Biochem Nutr. 2012 Mar; 50(2): 106-13.

Junichi Nagasawa, et al.

Exercise and oxidative stress in hypoxia

J Phys Fitness Sports Med. 2013; 2(4): 481-486.

Junichi Nagasawa, et al.

Oxidative Stress in Hypobaric and Normobaric Hypoxia and Antioxidant Effect of Oligonol

Japanese Journal of Mountain Medicine. 2010; 30: 118-124.

Tetsuya Okuyama, et al.

The Ameliorative Effect of the Oligomerized-polyphenol from Litchi chinensis Fruit Extract (OPLFE) on Temporary Physical Fatigue for University Track and Field Athletes -The Second Report Focused on the Subjective Assessments-

Japanese Pharmacology & Therapeutics. 2018; 46(8): 1425-1431.

Hideki Ohno, et al.

The Supplementation of Oligonol, the New Lychee Fruit-derived Polyphenol Converting into a Low-molecular Form, Has a Positive Effect on Fatigue during Regular Track-and-field Training in Young Athletes

Adv Exer Sport Physiol. 2008; 13(4): 93-99.

Mikio Nishizawa, et al.

Supplementation with a Flavanol-rich Lychee Fruit Extract Influences the Inflammatory Status of Young Athletes

Phytother Res. 2011 Oct; 25(10): 1486-93.

Jeong-Beom Lee, et al.

The effect of Oligonol intake on cortisol and related cytokines in healthy young men

Nutr Res Pract. 2010 Jun; 4(3): 203-7.

Miku Tsukamoto-Kusakabe, et al.

Effect of polyphenol converting into a low-molecular form on oxidative stress and serum total antioxidative capacity in high-intensity intermittent spring exercise

Japan Journal of Physical Education, Health and Sport Sciences. 2010; 45: 1-9.

Hideki Ohno, et al.

Antioxidant Supplementation in High Altitude Mountaineering: Focusing on Oligonol

Japanese Journal of Mountain Medicine. 2007; 27: 43-60.

Kentaro Kitadate, et al.

Effect of Lychee Fruit Extract (Oligonol) on Peripheral Circulation, a Pilot Study

Natural Medicine Journal. 2014; 6(7).

JeongBeom Lee, et al.

Oligonol Supplementation Modulates Plasma Volume and Osmolality and Sweating After Heat Load in Humans

J Med Food. 2015 May; 18(5): 578-83.

Jeong Beom Lee, et al.

Beneficial effect of Oligonol supplementation on sweating response under heat stress in humans

Food Funct. 2014 Oct; 5(10): 2516-20.

Young Oh Shin, et al.

Oligonol Supplementation Attenuates Body Temperature and the Circulating Levels of Prostaglandin E2 and Cyclooxygenase-2 After Heat Stress in Humans

J Med Food. 2013 Apr; 16(4): 318-23.

Young-Oh Shin, et al.

Effect of Oligonol Intake on Cortisol and Cytokines, and Body Temperature after Leg Immersion into Hot Water

Food Sci Biotechnol. 2011; 20(3): 659-663.

Young Oh Shin, et al.

The Effect of Oligonol Intake on Leukocytes, Serum HSP70, and Body Temperature after heat stress

J.KSLES. 2012; 19(1), 137-145.

Takahiro Maeda, et al.

Investigation of the Amelioration Effects of Oligonol® on Tinnitus in Randomized Double-blinded Placebo-controlled Trial

Japanese Pharmacology & Therapeutics. 2016; 44(9): 1329-1336.

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee peel, attenuates diabetes-induced pancreatic damage by inhibiting inflammatory responses via oxidative stress-dependent mitogen-activated protein kinase/nuclear factor-kappa B signaling

Phytother Res. 2018 Dec; 32(12): 2541-2550.

Himanshu Kumar Bhakta, et al.

Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B

Arch Pharm Res. 2017 Nov; 40(11): 1314-1327.

Jae Sue Choi, et al.

Inhibitory evaluation of oligonol on α-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and β-secretase 1 related to diabetes and Alzheimer’s disease

Arch Pharm Res. 2016; 39(3): 409-420.

Jeong Sook Noh, et al.

Treatment with Oligonol, a low-molecular Polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

Br J Nutr. 2011 Oct; 106(7): 1013-22.

Jun Takanari, et al.

Oligonol, a low molecular weight polyphenol of lychee fruit extract, suppresses absorption of glucose and fat

Clin Pharmacol Ther. 2017; 27(4): 195-205.

Hung-Wen Liu, et al.

Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle

Mol Nutr Food Res. 2016 Oct; 60(10): 2288-2296.

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats

Food Funct. 2016 Jul 13; 7(7): 3056-3063.

Hung-Wen Liu, et al.

Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice

Food Funct. 2016 Apr; 7(4): 1941-9.

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity mediated renal disorder in type 2 diabetic db/db mice

Drug Discov Ther. 2015 Feb; 9(1): 13-22.

Chan Hum Park, et al.

Oligonol, a Low-Molecular-Weight Polyphenol Derived from Lychee Fruit, Attenuates Diabetes-Induced Renal Damage through the Advanced Glycation End Product–Related Pathway in db/db Mice

J Nutr. 2014 Aug; 144(8): 1150-7.

Jeong Sook Noh, et al.

Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice.

Br J Nutr. 2010 Oct; 104(8): 1120-8.

Xiao-Hong Zhang, et al.

Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

Br J Pharmacol. 2010 Feb; 159(4): 928-38.

Yuji Moriwaki, et al.

Effects of Oligonol®, an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid

J Funct Foods. 2011; 3(1): 13-16.

Koji Wakame, et al.

Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells

J Biomed Transl Res. 2017; 1, 6-12.

Khota Hayashi, et al.

Oligonol, a Low-molecular Weight Polyphenol Extracted from Lychee Fruit, Modulates Cholesterol Metabolism in Rats within a Short Period

J Oleo Sci. 2020 Sep 2; 69(9): 1077-1085.

Jae-Yeo Park, et al.

Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model

BMC Complement Altern Med. 2015 Jun 16; 15: 185.

Junetsu Ogasawara, et al.

Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery

Nat Prod Commun. 2012 Sep; 7(9): 1193-6.

Junetsu Ogasawara, et al.

Comparison of the Effect of Oligonol, A New Lychee Fruit-derived Low Molecular Form of Polyphenol, and Epigallocatechin-3-gallate on Lipolysis in Rat Primary Adipocytes

Phytother Res. 2011 Mar;　25(3):　467-71.

Junetsu Ogasawara, et al.

Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/ Raf-1/ MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes

Biochem Biophys Res Commun. 2010 Nov 19; 402(3): 554-9.

Ryu Miyagawa, et al.

The effect of insulin on the production of plasminogen activator inhibitor type-1 in HepG2 cells

Heart. 2010; 42(9): 1153-1158.

Suhad M Bahijri, et al.

Oligonol Supplementation Decreases Cardiometabolic Risk Factors, and the Prevalence of Metabolic Syndrome in a Sample of Overweight and Obese Saudi Females

Annu Res Rev Biol. 2017; 16(2).

Hironobu Uchiyama, et al.

Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®)

Anticancer Res. 2016 Jul; 36(7): 3705-13.

Zaure Zhaparkhanova, et al.

Use of Oligonol® in Overweight and Obesity

Endocrinology Quick Report. 2018; 2(50): 31-34.

Masaki Taga, et al.

Anti-obesity effects of Oligonol in healthy subjects: a double blind, randomized placebo-controlled trial

Clinical Pharmacology and Therapy. 2016; 26(3): 85-96.

Jun Nishihira, et al.

Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee

J Funct Foods. 2009; 1(4): 341-348.

Suhad M Bahijri, et al.

Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females

Curr Nutr Food Sci. 2018 Apr; 14(2): 164-170.

Jae-Yeo Park, et al.

Inhibition of Adipogenesis by Oligonol through Akt-mTOR Inhibition in 3T3-L1 Adipocytes

Evid Based Complement Alternat Med. 2014; 2014: 895272.

Swati Kalgaonkar, et al.

Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and induces of metabolic syndrome in animal models

Phytother Res. 2010 Aug; 24(8): 1223-8.

Junetsu Ogasawara, et al.

Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway

Phytother Res. 2009 Nov; 23(11): 1626-33.

Takuya Sakurai, et al.

Antioxidative effects of a new lychee fruit derived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes

Biosci Biotechnol Biochem. 2008 Feb; 72(2): 463-76.

Koji Wakame

Functions of low molecular weight polyphenols from lychee fruit

FOOD STYLE 21. 2007; 125: 65.

Seul-Ki Park, et al.

Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway

Nutr Res Pract. 2016 Feb; 10(1): 3-10.

Joydeb Kumar Kundu, et al.

Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin

J Funct Foods. 2009; 1(1): 98-108.

Koji Wakame, et al.

Antibacterial and beautiful skin effects of low molecular weight polyphenols

Fragrance journal. 2009; 37(11): 65-68.

Takashi Tanaka, et al.

Production of oligomeric proanthocyanidins by fragmentation of polymers

Japanese Journal of Food Chemistry. 2007; 14(3): 134-139.

Asuka Yasueda, et al.

Review: Evidence-based Clinical Research of Anti-obesity Supplements in Japan

Immunol Endocr Metab Agents Med Chem. 2013 Aug; 13(3): 185-195.

Takuya Sakurai, et al.

Antioxidant effects of a novel low molecular weight polyphenol, Oligonol

FOOD FUNCTION. 2009; 5(1): 2-7.

Mamoru Onuma, et al.

The supplementation therapy of caine dermatology in my hospital

Japanese Journal of Small Animal Practice. 2008; 27(6): 340-346.

Jun Takanari, et al.

Anti-fatigue effects of Oligonol, a low-molecular-weight polyphenol, a “next-generation sports nutrition

FOOD STYLE 21. 2014; 209: 71-74.

Chikako Kuwabara, et al.

Analysis of supercooling activity of tannin-related polyphenols

Cryobiology. 2013 Aug; 67(1): 40-9.

Robert Fried, et al.

Multiple Protective Functions of Oligonol from Lychee

Type 2 Diabetes: Cardiovascular and Related Complications and Evidence-based Complementary Treatments (CHES). 2020: 269-273.

Yousef A Al-Dashti, et al.

Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance

J Am Coll Nutr. Sep-Oct 2018; 37(7): 553-567.

Kazumi Hayama, et al.

Health-promoting effects of a oligomerized polyphenol, oligonol on the athleates and elderly people

Bulletin of Sports and Medical Science. 2014; 6: 17-21.

Koji Wakame, et al.

Functions of a new generation of low molecular weight polyphenols (Oligonol)

aromatopia. 2011; 20(4): 87-91.

Jun Takanari, et al.

Functions of a new generation of low molecular weight polyphenols (Oligonol)

New Food Industry. 2011; 53(3): 9-21.

Takehito Miura, et al.

The Function of the Next Generation Polyphenol, “Oligonol”

Biotechnology in Functional Foods and Nutraceuticals. 2010: 91-101.

Takehito Miura, et al.

Functions of Oligonol, a New Generation Polyphenol

Japan Food Science. 2010; 49(1): 37-44.

Takehito Miura, et al.

The Function of the Next Generation of Polyphenol “Oligonol”

Japanese Journal of Complementary and Alternative Medicine. 2008; 5(3): 163-171.

Ryota Yamanishi, et al.

The Anti-inflammatory Effects of Flavanol-rich Lychee Fruit Extract in Rat Hepatocytes

PLoS One. 2014 Apr 4; 9(4): e93818.

Takumi Shibukawa, et al.

Absorption of Nitrogen Dioxide by the Polyphenol Solution

Kagaku kogaku ronbunshu. 2011; 37(2): 162-166.

Xiao Chen, et al.

Flavanol-rich lychee fruit extract substantially reduces progressive cognitive and molecular deficits in a triple-transgenic animal model of Alzheimer disease

Nutr Neurosci. 2019 Oct 11; 1-15.

Yoon Young Choi, et al.

Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer’s mouse model

Nutr Res. 2014 Jul; 34(7): 595-603.

Toru Ichinose, et al.

Evaluation of antiviral activity of Oligonol, an extract of Litchi chinensis, against betanodavirus

Drug Discov Ther. 2013 Dec; 7(6): 254-60.

Takuya Sakurai, et al.

Oligomerized lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells

Br J Nutr. 2013 Nov 14; 110(9): 1549-58.

K-J Kim, et al.

Oligonol prevented the relapse of dextran sulfate sodium-ulcerative colitis through enhancing NRF2-mediated antioxidative defense mechanism

J Physiol Pharmacol. 2018 Jun; 69(3).

Hye-Won Yum, et al.

Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice

Antioxid Redox Signal. 2013 Jul 10; 19(2): 102-14.

Hung-Wen Liu, et al.

Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1

Nutrients. 2017 Sep 20; 9(9): 1040.

Seong-Soo Roh, et al.

Low-Molecular-Weight Oligonol, a Polyphenol Derived from Lychee Fruit, Attenuates Experimental Reflux Esophagitis and HCl/Ethanol-Induced Gastric Ulcer

J Med Food. 2017 Dec; 20(12): 1214-1221.

Jeonghyeon Bak, et al.

Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NK-Kappa B and MAPK Signaling Pathways

Oxid Med Cell Longev. 2016; 2016: 3935841.

Jeong Beom Lee, et al.

Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans

Nutrients. 2014 Jun 24; 6(6): 2466-77.

Noboru Uchide, et al.

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Molecules. 2011 Feb 28; 16(3): 2032-52.

Leila Gangehei, et al.

Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation

Phytomedicine. 2010 Nov; 17(13): 1047-56.

Sung-Jae Lee, et al.

Inhibition of Lung Metastasis in Mice by Oligonol

Phytother Res. 2009 Jul; 23(7): 1043-6.

Jae Hyun Ahn, et al.

Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell

Nutr Res Pract. 2015 Apr; 9(2): 123-8.

Yoichi Nakagawa, et al.

Anti-Candida effectiveness of a candy containing citral, cinnamaldehyde, oligonol, and capric acid for oral candidiasis

Oral Therapeutics and Pharmacology. 2018; 37(3): 101-107.

Kazumi Hayama, et al.

Inhibitory effects of several saturated fatty acids and their related fatty alcohols on the growth of Candida albicans

Drug Discov Ther. 2015 Dec; 9(6): 386-90.

Kazumi Hayama, et al.

Development of a new aroma candy for maintenance of the oral health

Med Mycol Res. 2015; 6(1): 3-9.

Motofumi Suzuki, et al.

The Effects of an Aroma Candy on Oral Candida albicans Colony-forming Units (CFU) and Oral Hygiene States in Healthy Elderly Carrying Candida albicans

Medical Mycology Journal. 2015; 56: J31-J40.

Kazumi Hayama, et al.

Anti-Candida Activity of Aroma Candy and Its Protective Activity Against Murine Oral Candidiasis

Medical Mycology Journal. 2015; 56: J23-J29.

Kazumi Hayama, et al.

Therapeutic Effect of Oligonol, a Low-molecular Polyphenol Formulation Derived from Lychee Fruits on Murine Oral Candidiasis

Japanese Journal of Medical Mycology. 2010; 51(3): 137–142.

Miseon Kim, et al.

Oligonol, a Low Molecular Weight Polyphenol, Enhances Apoptotic Cell Death in Ovarian Cancer Cells via Suppressing NF-κB Activation

Nutr Cancer. 2019; 71(1): 141-148.

İlhan Öztekin, et al.

Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis

Evid Based Complement Alternat Med. 2015; 2015: 687196.

Hakan Akdere, et al.

Analgesic Effects of Oligonol, Acupuncture and Quantum Light Therapy on Chronic Nonbacterial Prostatitis

Iran Red Crescent Med J. 2015 Apr 25; 17(4): e26006.

Jun Kisugi, et al.

Suppression of N-Methyl-N-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

ABC. 2014; 4(2), 138-147.

Yun-Ching Chang, et al.

Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality

Mol Nutr Food Res. 2019 May; 63(10): e1801102.

Koji Wakame, et al.

Attempt to develop a sexual function-improving drink containing various natural food ingredients

FOOD STYLE 21. 2011; 165: 41-43.

Seizo Fujikawa, et al.

Supercooling-Promoting (Anti-ice Nucleation) Substances

Survival Strategies in Extreme Cold and Desiccation. 2018: 289-320.

Seizo Fujikawa, et al.

Current Research on Supercooling Accelerators

Functions and Applications of Antifreeze Protein. 2018: 180-190.

Toshie Koyama, et al.

Anti-ice nucleating activity of polyphenol compounds against silver iodide

Cryobiology. 2014 Oct; 69(2): 223-8.

Naeun Lee, et al.

Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes

Hum Immunol. 2016 Jun; 77(6): 512-5.

Kentaro Kitadate, et al.

Thirteen-week oral dose toxicity study of Oligonol containing oligomerized polyphenols extracted from lychee and green tea

Regul Toxicol Pharmacol. 2014 Feb; 68(1): 140-6.

Katsuhiko Suzuki, et al.

Functional Analyses of Oligonol by Novel Neutrophil Activity Measurement System

Japanese Journal of Complementary and Alternative Medicine. 2013; 10(1): 59-62.

Mahesh Thirunavukkarasu, et al.

Safety of oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on liver, kidney and heart function in rats

Toxicol Mech Methods. 2012 Sep; 22(7): 555-9.

Hajime Fujii, et al.

Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts

Food Chem Toxicol. 2008 Dec; 46(12): 3553-62.