Oligonol®

論文

THESIS研究論文一覧

これまで世界中の大学・研究機関でOligonolに関する研究が手掛けられ、数多くの論文が発表されています。

運動

身体的疲労

奥山哲矢ら

大学陸上選手を対象とした低分子化ライチポリフェノールの一時的身体疲労感軽減作用~体感性評価を主とした第二報~

薬理と治療. 2018; 46(8): 1425-1431.

臨床
身体的疲労

Hideki Ohno, et al.

The Supplementation of Oligonol, the New Lychee Fruit-derived Polyphenol Converting into a Low-molecular Form, Has a Positive Effect on Fatigue during Regular Track-and-field Training in Young Athletes

Adv Exer Sport Physiol. 2008; 13(4): 93-99.

臨床
運動パフォーマンス

Seung Wan Kang, et al.

Oligomerized lychee fruit extract (OLFE) and a mixture of vitamin C and vitamin E for endurance capacity in a double blind randomized controlled trial

J Clin Biochem Nutr. 2012 Mar; 50(2): 106-13.

臨床
運動パフォーマンス

杉田正明ら

Oligonol®摂取が運動パフォーマンスを向上させることが明らかに

hys Act Nutr. 2021; 25(3):8-15

臨床
登山・低酸素症

Junichi Nagasawa, et al.

Exercise and oxidative stress in hypoxia

J Phys Fitness Sports Med. 2013; 2(4): 481-486.

臨床
登山・低酸素症

長澤純一ら

低圧・低酸素環境が引き起こす酸化ストレスとオリゴノールの抗酸化効果

Japanese Journal of Mountain Medicine. 2010; 30: 118-124.

臨床

Mikio Nishizawa, et al.

Supplementation with a Flavanol-rich Lychee Fruit Extract Influences the Inflammatory Status of Young Athletes

Phytother Res. 2011 Oct; 25(10): 1486-93.

臨床

Jeong-Beom Lee, et al.

The effect of Oligonol intake on cortisol and related cytokines in healthy young men

Nutr Res Pract. 2010 Jun; 4(3): 203-7.

臨床

塚本(日下部)未来ら

低分子化ポリフェノールの摂取が高強度間欠的運動時の酸化ストレスおよび血清総抗酸化能に与える影響

北海道体育学研究. 2010; 45: 1-9.

臨床

大野秀樹ら

高所登山における抗酸化サプリメント摂取の意義-Oligonolを中心として-

Japanese Journal of Mountain Medicine. 2007; 27: 43-60.

臨床

血流

血流

Kentaro Kitadate, et al.

Effect of Lychee Fruit Extract (Oligonol) on Peripheral Circulation, a Pilot Study

Natural Medicine Journal. 2014; 6(7).

臨床
熱中症

Young Oh Shin, et al.

Oligonol Supplementation Attenuates Body Temperature and the Circulating Levels of Prostaglandin E2 and Cyclooxygenase-2 After Heat Stress in Humans

J Med Food. 2013 Apr; 16(4): 318-23.

臨床
熱中症

JeongBeom Lee, et al.

Oligonol Supplementation Modulates Plasma Volume and Osmolality and Sweating After Heat Load in Humans

J Med Food. 2015 May; 18(5): 578-83.

臨床
熱中症

Jeong Beom Lee, et al.

Beneficial effect of Oligonol supplementation on sweating response under heat stress in humans

Food Funct. 2014 Oct; 5(10): 2516-20.

臨床
熱中症

Young-Oh Shin, et al.

Effect of Oligonol Intake on Cortisol and Cytokines, and Body Temperature after Leg Immersion into Hot Water

Food Sci Biotechnol. 2011; 20(3): 659-663.

臨床
熱中症・免疫調節

Young Oh Shin, et al.

The Effect of Oligonol Intake on Leukocytes, Serum HSP70, and Body Temperature after heat stress

J.KSLES. 2012; 19(1), 137-145.

基礎
免疫調節

Jeong Beom Lee, et al.

Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans

Nutrients. 2014 Jun 24; 6(6): 2466-77.

臨床
耳鳴り

前田哲宏ら

プラセボ対照二重盲検並行群間比較試験によるOligonol®の耳鳴り軽減作用の検証

薬理と治療. 2016; 44(9): 1329-1336.

臨床

生活習慣病

メタボリック症候群

Hironobu Uchiyama, et al.

Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®)

Anticancer Res. 2016 Jul; 36(7): 3705-13.

基礎
メタボリック症候群

Suhad M Bahijri, et al.

Oligonol Supplementation Decreases Cardiometabolic Risk Factors, and the Prevalence of Metabolic Syndrome in a Sample of Overweight and Obese Saudi Females

Annu Res Rev Biol. 2017; 16(2).

臨床
肥満症・高脂血症・糖尿病

若命浩二

ライチ果実由来低分子化ポリフェノールの機能性

FOOD STYLE 21. 2007; 125: 65.

総説
肥満症・高脂血症

Suhad M Bahijri, et al.

Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females

Curr Nutr Food Sci. 2018 Apr; 14(2): 164-170.

臨床
肥満症・高脂血症

Jae-Yeo Park, et al.

Inhibition of Adipogenesis by Oligonol through Akt-mTOR Inhibition in 3T3-L1 Adipocytes

Evid Based Complement Alternat Med. 2014; 2014: 895272.

基礎
肥満症・高脂血症

Swati Kalgaonkar, et al.

Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and induces of metabolic syndrome in animal models

Phytother Res. 2010 Aug; 24(8): 1223-8.

基礎
肥満症・高脂血症

Junetsu Ogasawara, et al.

Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway

Phytother Res. 2009 Nov; 23(11): 1626-33.

基礎
肥満症・高脂血症

Takuya Sakurai, et al.

Antioxidative effects of a new lychee fruit derived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes

Biosci Biotechnol Biochem. 2008 Feb; 72(2): 463-76.

基礎
肥満症

Zaure Zhaparkhanova, et al.

過体重および肥満におけるOligonol®の利用

内分泌学速報(※ロシア語). 2018; 2(50): 31-34.

基礎
肥満症

多賀昌樹ら

健常若年女性におけるOligonol摂取による肥満予防効果 ―ランダム化プラセボ対照二重盲検試験―

薬理と臨床. 2016; 26(3): 85-96.

臨床
肥満症

Jun Nishihira, et al.

Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee

J Funct Foods. 2009; 1(4): 341-348.

臨床
糖尿病

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee peel, attenuates diabetes-induced pancreatic damage by inhibiting inflammatory responses via oxidative stress-dependent mitogen-activated protein kinase/nuclear factor-kappa B signaling

Phytother Res. 2018 Dec; 32(12): 2541-2550.

基礎
糖尿病

Himanshu Kumar Bhakta, et al.

Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B

Arch Pharm Res. 2017 Nov; 40(11): 1314-1327.

基礎
糖尿病・膵保護

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats

Food Funct. 2016 Jul 13; 7(7): 3056-3063.

基礎
糖尿病・腎保護

Hung-Wen Liu, et al.

Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice

Food Funct. 2016 Apr; 7(4): 1941-9.

基礎
糖尿病・腎保護

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity mediated renal disorder in type 2 diabetic db/db mice

Drug Discov Ther. 2015 Feb; 9(1): 13-22.

基礎
糖尿病・腎保護

Chan Hum Park, et al.

Oligonol, a Low-Molecular-Weight Polyphenol Derived from Lychee Fruit, Attenuates Diabetes-Induced Renal Damage through the Advanced Glycation End Product–Related Pathway in db/db Mice

J Nutr. 2014 Aug; 144(8): 1150-7.

基礎
糖尿病・腎保護

Jeong Sook Noh, et al.

Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice.

Br J Nutr. 2010 Oct; 104(8): 1120-8.

基礎
糖尿病・サルコペニア

Hung-Wen Liu, et al.

Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1

Nutrients. 2017 Sep 20; 9(9): 1040.

基礎
糖尿病・高脂血症・サルコペニア

Hung-Wen Liu, et al.

Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle

Mol Nutr Food Res. 2016 Oct; 60(10): 2288-2296.

基礎
糖尿病・肝保護

Jeong Sook Noh, et al.

Treatment with Oligonol, a low-molecular Polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

Br J Nutr. 2011 Oct; 106(7): 1013-22.

基礎
糖尿病・アルツハイマー病

Jae Sue Choi, et al.

Inhibitory evaluation of oligonol on α-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and β-secretase 1 related to diabetes and Alzheimer’s disease

Arch Pharm Res. 2016; 39(3): 409-420.

基礎
糖尿病・高脂血症

Jun Takanari, et al.

Oligonol, a low molecular weight polyphenol of lychee fruit extract, suppresses absorption of glucose and fat

Clin Pharmacol Ther. 2017; 27(4): 195-205.

基礎
糖尿病・血管内皮機能

Xiao-Hong Zhang, et al.

Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

Br J Pharmacol. 2010 Feb; 159(4): 928-38.

基礎
高脂血症

Khota Hayashi, et al.

Oligonol, a Low-molecular Weight Polyphenol Extracted from Lychee Fruit, Modulates Cholesterol Metabolism in Rats within a Short Period

J Oleo Sci. 2020 Sep 2; 69(9): 1077-1085.

基礎
高脂血症

Jae-Yeo Park, et al.

Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model

BMC Complement Altern Med. 2015 Jun 16; 15: 185.

基礎
高脂血症

Junetsu Ogasawara, et al.

Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery

Nat Prod Commun. 2012 Sep; 7(9): 1193-6.

基礎
高脂血症

Junetsu Ogasawara, et al.

Comparison of the Effect of Oligonol, A New Lychee Fruit-derived Low Molecular Form of Polyphenol, and Epigallocatechin-3-gallate on Lipolysis in Rat Primary Adipocytes

Phytother Res. 2011 Mar; 25(3): 467-71.

基礎
高脂血症

Junetsu Ogasawara, et al.

Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/ Raf-1/ MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes

Biochem Biophys Res Commun. 2010 Nov 19; 402(3): 554-9.

基礎
高脂血症・血栓

宮川隆ら

HepG2細胞におけるインスリンと酸化ストレスのPAI-1産生に対する影響の解析:メタボリックシンドロームの易血栓性の病態解明を指向して

心臓. 2010; 42(9): 1153-1158.

基礎
痛風

Yuji Moriwaki, et al.

Effects of Oligonol®, an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid

J Funct Foods. 2011; 3(1): 13-16.

臨床
脱毛症

Koji Wakame, et al.

Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells

J Biomed Transl Res. 2017; 1, 6-12.

基礎
サーチュイン・オートファジー

Seul-Ki Park, et al.

Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway

Nutr Res Pract. 2016 Feb; 10(1): 3-10.

基礎

美容

皮膚保護

Joydeb Kumar Kundu, et al.

Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin

J Funct Foods. 2009; 1(1): 98-108.

基礎

若命浩二ら

低分子化ポリフェノールの抗菌および美容作用

フレグランスジャーナル. 2009; 37(11): 65-68.

臨床

総説

肥満症・高脂血症

櫻井拓也ら

新規低分子化ポリフェノールOligonolの抗酸化作用

FOOD FUNCTION. 2009; 5(1): 2-7.

総説
肥満症

Asuka Yasueda, et al.

Review: Evidence-based Clinical Research of Anti-obesity Supplements in Japan

Immunol Endocr Metab Agents Med Chem. 2013 Aug; 13(3): 185-195.

総説
動物(ペット)

小沼守ら

当院の犬皮膚科におけるサプリメント療法

小動物臨床. 2008; 27(6): 340-346.

獣医
製造方法

田中隆ら

ポリマー断片化によるプロアントシアニジンオリゴマーの製造方法

日本食品化学学会誌. 2007; 14(3): 134-139.

基礎
身体的疲労

高成準ら

次世代スポーツニュートリション」低分子化ポリフェノールOligonolの抗疲労効果

FOOD STYLE 21. 2014; 209: 71-74.

総説
過冷却促進

Chikako Kuwabara, et al.

Analysis of supercooling activity of tannin-related polyphenols

Cryobiology. 2013 Aug; 67(1): 40-9.

総説

Robert Fried, et al.

Multiple Protective Functions of Oligonol from Lychee

Type 2 Diabetes: Cardiovascular and Related Complications and Evidence-based Complementary Treatments (CHES). 2020: 269-273.

書籍

Yousef A Al-Dashti, et al.

Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance

J Am Coll Nutr. Sep-Oct 2018; 37(7): 553-567.

総説

羽山和美ら

スポーツマンおよび高齢者の健康増進のための低分子化ポリフェノール

帝京大学スポーツ医療研究. 2014; 6: 17-21.

総説

高成準ら

新世代の低分子化ポリフェノール(Oligonol)の機能

New Food Industry. 2011; 53(3): 9-21.

総説

若命浩二ら

新世代の低分子化ポリフェノール(Oligonol)の機能

aromatopia. 2011; 20(4): 87-91.

総説

Takehito Miura, et al.

The Function of the Next Generation Polyphenol, “Oligonol”

Biotechnology in Functional Foods and Nutraceuticals. 2010: 91-101.

書籍

三浦健人ら

新世代のポリフェノール“Oligonol(オリゴノール)”の機能

ジャパンフードサイエンス. 2010; 49(1): 37-44.

総説

三浦健人ら

新世代ポリフェノール“Oligonol(オリゴノール)”の機能

日本補完代替医療学会誌. 2008; 5(3): 163-171.

総説

その他

悪性黒色腫・肺転移

Sung-Jae Lee, et al.

Inhibition of Lung Metastasis in Mice by Oligonol

Phytother Res. 2009 Jul; 23(7): 1043-6.

基礎
卵巣がん

Miseon Kim, et al.

Oligonol, a Low Molecular Weight Polyphenol, Enhances Apoptotic Cell Death in Ovarian Cancer Cells via Suppressing NF-κB Activation

Nutr Cancer. 2019; 71(1): 141-148.

基礎
網膜保護

Jun Kisugi, et al.

Suppression of N-Methyl-N-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

ABC. 2014; 4(2), 138-147.

基礎
ベータノダウイルス

Toru Ichinose, et al.

Evaluation of antiviral activity of Oligonol, an extract of Litchi chinensis, against betanodavirus

Drug Discov Ther. 2013 Dec; 7(6): 254-60.

基礎
日和見感染・カンジダ

中川洋一ら

シトラール,シンナムアルデヒド,オリゴノール®,カプリン酸を含有する飴の口腔カンジダ症に対する効果

歯科薬物療法. 2018; 37(3): 101-107.

臨床
日和見感染・カンジダ

羽山和美ら

口腔内衛生環境の改善のためのアロマキャンディの開発

Med Mycol Res. 2015; 6(1): 3-9.

臨床
日和見感染・カンジダ

鈴木基文ら

カンジダ保有高齢者の口腔カンジダ生菌数および口腔内衛生に及ぼすアロマキャンディ摂取の影響に関する研究

Medical Mycology Journal. 2015; 56: J31-J40.

臨床
日和見感染・カンジダ

羽山和美ら

アロマキャンディのカンジダ発育阻止能とマウス口腔カンジダ症に対する防御効果

Medical Mycology Journal. 2015; 56: J23-J29.

基礎
日和見感染・カンジダ

Kazumi Hayama, et al.

Inhibitory effects of several saturated fatty acids and their related fatty alcohols on the growth of Candida albicans

Drug Discov Ther. 2015 Dec; 9(6): 386-90.

基礎
日和見感染・カンジダ

羽山和美ら

口腔カンジダ症に対するOligonolの効果

日本医真菌学会雑誌. 2010; 51(3): 137–142.

基礎
認知機能

Takuya Sakurai, et al.

Oligomerized lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells

Br J Nutr. 2013 Nov 14; 110(9): 1549-58.

基礎
大腸炎

K-J Kim, et al.

Oligonol prevented the relapse of dextran sulfate sodium-ulcerative colitis through enhancing NRF2-mediated antioxidative defense mechanism

J Physiol Pharmacol. 2018 Jun; 69(3).

基礎
大腸炎

Hye-Won Yum, et al.

Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice

Antioxid Redox Signal. 2013 Jul 10; 19(2): 102-14.

基礎
大気汚染

澁川卓実ら

ポリフェノール水溶液による二酸化窒素の吸収

化学工学論文集. 2011; 37(2): 162-166.

基礎
前立腺炎

İlhan Öztekin, et al.

Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis

Evid Based Complement Alternat Med. 2015; 2015: 687196.

基礎
前立腺炎

Hakan Akdere, et al.

Analgesic Effects of Oligonol, Acupuncture and Quantum Light Therapy on Chronic Nonbacterial Prostatitis

Iran Red Crescent Med J. 2015 Apr 25; 17(4): e26006.

基礎
精力

若命浩二ら

各種天然食品素材等を配合した精力改善(性機能改善)EDドリンクの開発の試み

FOOD STYLE 21. 2011; 165: 41-43.

臨床
神経変性疾患

Jae Hyun Ahn, et al.

Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell

Nutr Res Pract. 2015 Apr; 9(2): 123-8.

基礎
食道炎・胃潰瘍

Seong-Soo Roh, et al.

Low-Molecular-Weight Oligonol, a Polyphenol Derived from Lychee Fruit, Attenuates Experimental Reflux Esophagitis and HCl/Ethanol-Induced Gastric Ulcer

J Med Food. 2017 Dec; 20(12): 1214-1221.

基礎
サルコペニア

Yun-Ching Chang, et al.

Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality

Mol Nutr Food Res. 2019 May; 63(10): e1801102.

基礎
作用機序

Ryota Yamanishi, et al.

The Anti-inflammatory Effects of Flavanol-rich Lychee Fruit Extract in Rat Hepatocytes

PLoS One. 2014 Apr 4; 9(4): e93818.

基礎
抗酸化

鈴木克彦ら

新規好中球機能検査法によるオリゴノールの機能解析

日本補完代替医療学会誌. 2013; 10(1): 59-62.

基礎
抗炎症

Naeun Lee, et al.

Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes

Hum Immunol. 2016 Jun; 77(6): 512-5.

基礎
肝炎

Jeonghyeon Bak, et al.

Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NK-Kappa B and MAPK Signaling Pathways

Oxid Med Cell Longev. 2016; 2016: 3935841.

基礎
過冷却促進

藤川清三ら

過冷却促進物質の研究の現状

不凍タンパク質の機能と応用. 2018: 180-190.

書籍
過冷却促進

Seizo Fujikawa, et al.

Supercooling-Promoting (Anti-ice Nucleation) Substances

Survival Strategies in Extreme Cold and Desiccation. 2018: 289-320.

書籍
過冷却促進

Toshie Koyama, et al.

Anti-ice nucleating activity of polyphenol compounds against silver iodide

Cryobiology. 2014 Oct; 69(2): 223-8.

基礎
インフルエンザ

Noboru Uchide, et al.

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Molecules. 2011 Feb 28; 16(3): 2032-52.

基礎
インフルエンザ

Leila Gangehei, et al.

Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation

Phytomedicine. 2010 Nov; 17(13): 1047-56.

基礎
アルツハイマー病

Xiao Chen, et al.

Flavanol-rich lychee fruit extract substantially reduces progressive cognitive and molecular deficits in a triple-transgenic animal model of Alzheimer disease

Nutr Neurosci. 2019 Oct 11; 1-15.

基礎
アルツハイマー病

Yoon Young Choi, et al.

Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer’s mouse model

Nutr Res. 2014 Jul; 34(7): 595-603.

基礎
安全性

Kentaro Kitadate, et al.

Thirteen-week oral dose toxicity study of Oligonol containing oligomerized polyphenols extracted from lychee and green tea

Regul Toxicol Pharmacol. 2014 Feb; 68(1): 140-6.

基礎
安全性

Mahesh Thirunavukkarasu, et al.

Safety of oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on liver, kidney and heart function in rats

Toxicol Mech Methods. 2012 Sep; 22(7): 555-9.

基礎
安全性

Hajime Fujii, et al.

Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts

Food Chem Toxicol. 2008 Dec; 46(12): 3553-62.

基礎

研究データと実績