論文

河村亜希ら

Oligomerized polyphenols in lychee fruit extract supplements may improve high-intensity exercise performance in male athletes: a pilot study

Phys Act Nutr. 2021; 25(3): 8-15.

Seung Wan Kang, et al.

Oligomerized lychee fruit extract (OLFE) and a mixture of vitamin C and vitamin E for endurance capacity in a double blind randomized controlled trial

J Clin Biochem Nutr. 2012; 50(2): 106-13.

奥山哲矢ら

大学陸上選手を対象とした低分子化ライチポリフェノールの一時的身体疲労感軽減作用～体感性評価を主とした第二報～

薬理と治療. 2018; 46(8): 1425-1431.

大野秀樹ら

The Supplementation of Oligonol, the New Lychee Fruit-derived Polyphenol Converting into a Low-molecular Form, Has a Positive Effect on Fatigue during Regular Track-and-field Training in Young Athletes

Adv Exer Sport Physiol. 2008; 13(4): 93-99.

長澤純一ら

Exercise and oxidative stress in hypoxia

J Phys Fitness Sports Med. 2013; 2(4): 481-486.

長澤純一ら

低圧・低酸素環境が引き起こす酸化ストレスとオリゴノールの抗酸化効果

Japanese Journal of Mountain Medicine. 2010; 30: 118-124.

西澤幹雄ら

Supplementation with a Flavanol-rich Lychee Fruit Extract Influences the Inflammatory Status of Young Athletes

Phytother Res. 2011; 25(10): 1486-93.

Jeong-Beom Lee, et al.

The effect of Oligonol intake on cortisol and related cytokines in healthy young men

Nutr Res Pract. 2010; 4(3): 203-7.

塚本（日下部）未来ら

低分子化ポリフェノールの摂取が高強度間欠的運動時の酸化ストレスおよび血清総抗酸化能に与える影響

北海道体育学研究. 2010; 45: 1-9.

大野秀樹ら

高所登山における抗酸化サプリメント摂取の意義－Oligonolを中心として－

Japanese Journal of Mountain Medicine. 2007; 27: 43-60.

脇英彰ら

Effects of a Standardized Oligomerized-Polyphenol from Litchi chinensis Fruit Extract and Mixed Plant Extract Supplementation on Peripheral Circulation and Cold Sensitivity

J Nutr Sci Vitaminol. 2020; 66(3): 255-260.

北舘健太郎ら

Effect of Lychee Fruit Extract (Oligonol) on Peripheral Circulation, a Pilot Study

Natural Medicine Journal. 2014; 6(7).

Jeong Beom Lee, et al.

Oligonol Supplementation Modulates Plasma Volume and Osmolality and Sweating After Heat Load in Humans

J Med Food. 2015; 18(5): 578-83.

Jeong Beom Lee, et al.

Beneficial effect of Oligonol supplementation on sweating response under heat stress in humans

Food Funct. 2014; 5(10): 2516-20.

Young-Oh Shin, et al.

Oligonol Supplementation Attenuates Body Temperature and the Circulating Levels of Prostaglandin E2 and Cyclooxygenase-2 After Heat Stress in Humans

J Med Food. 2013; 16(4): 318-23.

Young-Oh Shin, et al.

Effect of Oligonol Intake on Cortisol and Cytokines, and Body Temperature after Leg Immersion into Hot Water

Food Sci Biotechnol. 2011; 20(3): 659-663.

Young-Oh Shin, et al.

The Effect of Oligonol Intake on Leukocytes, Serum HSP70, and Body Temperature after heat stress

J.KSLES. 2012; 19(1), 137-145.

金子剛ら

健常の範囲ながら日常的に耳に違和感を有する者に対するイチョウ葉エキスおよび低分子化ライチポリフェノール配合食品の摂取による改善効果の検討：無作為ランダム化二重盲検プラセボ対照並行群間比較試験

診療と新薬. 2023; 60: 153-164.

前田哲宏ら

プラセボ対照二重盲検並行群間比較試験によるOligonol®の耳鳴り軽減作用の検証

薬理と治療. 2016; 44(9): 1329-1336.

Thananya Jinato, et al.

Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study

Nutrients. 2022; 14(14): 2921.

Suhad M Bahijri, et al.

Oligonol Supplementation Decreases Cardiometabolic Risk Factors, and the Prevalence of Metabolic Syndrome in a Sample of Overweight and Obese Saudi Females

Annu Res Rev Biol. 2017; 16(2).

内山博充ら

Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®)

Anticancer Res. 2016; 36(7): 3705-13.

Jeong Hun Kim, et al.

Effect of oligonol, a lychee-derived polyphenol, on skeletal muscle in ovariectomized rats by regulating body composition, protein turnover, and mitochondrial quality signaling

Food Sci Nutr. 2022; 10(4): 1184-1194.

Suhad M Bahijri, et al.

Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females

Curr Nutr Food Sci. 2018; 14(2): 164-170.

Jae-Yeo Park, et al.

Inhibition of Adipogenesis by Oligonol through Akt-mTOR Inhibition in 3T3-L1 Adipocytes

Evid Based Complement Alternat Med. 2014; 2014: 895272.

Swati Kalgaonkar, et al.

Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and induces of metabolic syndrome in animal models

Phytother Res. 2010; 24(8): 1223-8.

小笠原準悦ら

Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway

Phytother Res. 2009; 23(11): 1626-33.

櫻井拓也ら

Antioxidative effects of a new lychee fruit derived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes

Biosci Biotechnol Biochem. 2008; 72(2): 463-76.

佐藤かおりら

卵巣摘出ラットに対する低分子化ライチポリフェノール「Oligonol®」の肥満予防効果

和洋女子大学紀要. 2021; 62: 33-41.

Zaure Zhaparkhanova, et al.

過体重および肥満におけるOligonol®の利用

内分泌学速報（※ロシア語）. 2018; 2(50): 31-34.

多賀昌樹ら

健常若年女性におけるOligonol摂取による肥満予防効果　―ランダム化プラセボ対照二重盲検試験―

薬理と臨床. 2016; 26(3): 85-96.

西平順ら

Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee

J Funct Foods. 2009; 1(4): 341-348.

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee peel, attenuates diabetes-induced pancreatic damage by inhibiting inflammatory responses via oxidative stress-dependent mitogen-activated protein kinase/nuclear factor-kappa B signaling

Phytother Res. 2018; 32(12): 2541-2550.

Himanshu Kumar Bhakta, et al.

Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B

Arch Pharm Res. 2017; 40(11): 1314-1327.

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats

Food Funct. 2016; 7(7): 3056-3063.

Jeong Sook Noh, et al.

Treatment with Oligonol, a low-molecular Polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

Br J Nutr. 2011; 106(7): 1013-22.

Hung-Wen Liu, et al.

Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice

Food Funct. 2016; 7(4): 1941-9.

Chan Hum Park, et al.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity mediated renal disorder in type 2 diabetic db/db mice

Drug Discov Ther. 2015; 9(1): 13-22.

Chan Hum Park, et al.

Oligonol, a Low-Molecular-Weight Polyphenol Derived from Lychee Fruit, Attenuates Diabetes-Induced Renal Damage through the Advanced Glycation End Product–Related Pathway in db/db Mice

J Nutr. 2014; 144(8): 1150-7.

Jeong Sook Noh, et al.

Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice.

Br J Nutr. 2010; 104(8): 1120-8.

Hung-Wen Liu, et al.

Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1

Nutrients. 2017; 9(9): 1040.

高成準ら

Oligonol, a low molecular weight polyphenol of lychee fruit extract, suppresses absorption of glucose and fat

Clin Pharmacol Ther. 2017; 27(4): 195-205.

Hung-Wen Liu, et al.

Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle

Mol Nutr Food Res. 2016; 60(10): 2288-2296.

Jae Sue Choi, et al.

Inhibitory evaluation of oligonol on α-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and β-secretase 1 related to diabetes and Alzheimer’s disease

Arch Pharm Res. 2016; 39(3): 409-420.

Xiao-Hong Zhang, et al.

Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

Br J Pharmacol. 2010; 159(4): 928-38.

若命浩二

ライチ果実由来低分子化ポリフェノールの機能性

FOOD STYLE 21. 2007; 125: 65.

Khota Hayashi, et al.

Oligonol, a Low-molecular Weight Polyphenol Extracted from Lychee Fruit, Modulates Cholesterol Metabolism in Rats within a Short Period

J Oleo Sci. 2020; 69(9): 1077-1085.

Jae-Yeo Park, et al.

Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model

BMC Complement Altern Med. 2015; 15: 185.

小笠原準悦ら

Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery

Nat Prod Commun. 2012; 7(9): 1193-6.

小笠原準悦ら

Comparison of the Effect of Oligonol, A New Lychee Fruit-derived Low Molecular Form of Polyphenol, and Epigallocatechin-3-gallate on Lipolysis in Rat Primary Adipocytes

Phytother Res. 2011; 25(3): 467-71.

小笠原準悦ら

Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/ Raf-1/ MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes

Biochem Biophys Res Commun. 2010; 402(3): 554-9.

宮川隆ら

HepG2細胞におけるインスリンと酸化ストレスのPAI-1産生に対する影響の解析：メタボリックシンドロームの易血栓性の病態解明を指向して

心臓. 2010; 42(9): 1153-1158.

森脇優司ら

Effects of Oligonol®, an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid

J Funct Foods. 2011; 3(1): 13-16.

若命浩二ら

Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells

J Biomed Transl Res. 2017; 1, 6-12.

Seul-Ki Park, et al.

Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway

Nutr Res Pract. 2016; 10(1): 3-10.

Joydeb Kumar Kundu, et al.

Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin

J Funct Foods. 2009; 1(1): 98-108.

若命浩二ら

低分子化ポリフェノールの抗菌および美容作用

フレグランスジャーナル. 2009; 37(11): 65-68.

塩拓磨ら

アスリートサポート素材：Oligonol®の抗疲労効果

FOOD STYLE 21. 2021; 25(5): 52-56.

高成準ら

「次世代スポーツニュートリション」低分子化ポリフェノールOligonolの抗疲労効果

FOOD STYLE 21. 2014; 209: 71-74.

櫻井拓也ら

新規低分子化ポリフェノールOligonolの抗酸化作用

FOOD FUNCTION. 2009; 5(1): 2-7.

安枝明日香ら

Review: Evidence-based Clinical Research of Anti-obesity Supplements in Japan

Immunol Endocr Metab Agents Med Chem. 2013; 13(3): 185-195.

小沼守ら

当院の犬皮膚科におけるサプリメント療法

小動物臨床. 2008; 27(6): 340-346.

田中隆ら

ポリマー断片化によるプロアントシアニジンオリゴマーの製造方法

日本食品化学学会誌. 2007; 14(3): 134-139.

Robert Fried, et al.

Multiple Protective Functions of Oligonol from Lychee

Type 2 Diabetes: Cardiovascular and Related Complications and Evidence-based Complementary Treatments (CHES). 2020: 269-273.

Yousef A Al-Dashti, et al.

Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance

J Am Coll Nutr. 2018; 37(7): 553-567.

羽山和美ら

スポーツマンおよび高齢者の健康増進のための低分子化ポリフェノール

帝京大学スポーツ医療研究. 2014; 6: 17-21.

高成準ら

新世代の低分子化ポリフェノール（Oligonol）の機能

New Food Industry. 2011; 53(3): 9-21.

若命浩二ら

新世代の低分子化ポリフェノール（Oligonol）の機能

aromatopia. 2011; 20(4): 87-91.

三浦健人ら

The Function of the Next Generation Polyphenol, “Oligonol”

Biotechnology in Functional Foods and Nutraceuticals. 2010: 91-101.

三浦健人ら

新世代のポリフェノール“Oligonol（オリゴノール）”の機能

ジャパンフードサイエンス. 2010; 49(1): 37-44.

三浦健人ら

新世代ポリフェノール“Oligonol（オリゴノール）”の機能

日本補完代替医療学会誌. 2008; 5(3): 163-171.

石田晃裕ら

Influence of Chewing Gummy Jelly Containing Aroma Compound on Psychological Stress and Autonomic Nervous System Activity: A Randomized Crossover Trial

Bull Tokyo Dent Coll. 2023.

Li-Ning Peng, et al.

Clinical efficacy of oligonol® supplementation on metabolism and muscle health in middle-aged and older adults: A double-blinded randomized controlled trial

Arch Gerontol Geriatr. 2022; 103: 104784.

Yun-Ching Chang, et al.

Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality

Mol Nutr Food Res. 2019; 63(10): e1801102.

小島三枝ら

特別養護老人ホームの口腔ケアにおけるアロマキャンディの有用性

日本摂食嚥下リハビリテーション学会雑誌. 2021; 25(2): 120-128

中川洋一ら

シトラール，シンナムアルデヒド，オリゴノール®，カプリン酸を含有する飴の口腔カンジダ症に対する効果

歯科薬物療法. 2018; 37(3): 101-107.

羽山和美ら

口腔内衛生環境の改善のためのアロマキャンディの開発

Med Mycol Res. 2015; 6(1): 3-9.

鈴木基文ら

カンジダ保有高齢者の口腔カンジダ生菌数および口腔内衛生に及ぼすアロマキャンディ摂取の影響に関する研究

Medical Mycology Journal. 2015; 56: J31-J40.

羽山和美ら

アロマキャンディのカンジダ発育阻止能とマウス口腔カンジダ症に対する防御効果

Medical Mycology Journal. 2015; 56: J23-J29.

羽山和美ら

Inhibitory effects of several saturated fatty acids and their related fatty alcohols on the growth of Candida albicans

Drug Discov Ther. 2015; 9(6): 386-90.

羽山和美ら

口腔カンジダ症に対するOligonolの効果

日本医真菌学会雑誌. 2010; 51(3): 137–142.

一ノ瀬亨ら

Evaluation of antiviral activity of Oligonol, an extract of Litchi chinensis, against betanodavirus

Drug Discov Ther. 2013; 7(6): 254-60.

内出昇ら

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Molecules. 2011; 16(3): 2032-52.

Leila Gangehei, et al.

Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation

Phytomedicine. 2010; 17(13): 1047-56.

Jeong Hun Kim, et al.

Effects of oligonol on the submandibular gland in ovariectomized rats

Biomed Pharmacother. 2021; 141: 111897.

来生淳ら

Suppression of N-Methyl-N-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation

ABC. 2014; 4(2), 138-147.

Jihyun Kim, et al.

Integrative Transcriptomic Analysis Reveals Upregulated Apoptotic Signaling in Wound-Healing Pathway in Rat Liver Fibrosis Models

Antioxidants. 2023; 12(8): 1588.

Changyong Lee, et al.

Protective Effect of Oligonol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats via the JNK/NF-κB and PI3K/Akt/Nrf2 Signaling Pathways

Antioxidants. 2021; 10(3): 366.

Jeong Beom Lee, et al.

Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans

Nutrients. 2014; 6(6): 2466-77.

K-J Kim, et al.

Oligonol prevented the relapse of dextran sulfate sodium-ulcerative colitis through enhancing NRF2-mediated antioxidative defense mechanism

J Physiol Pharmacol. 2018; 69(3).

Hye-Won Yum, et al.

Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice

Antioxid Redox Signal. 2013; 19(2): 102-14.

İlhan Öztekin, et al.

Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis

Evid Based Complement Alternat Med. 2015; 2015: 687196.

Hakan Akdere, et al.

Analgesic Effects of Oligonol, Acupuncture and Quantum Light Therapy on Chronic Nonbacterial Prostatitis

Iran Red Crescent Med J. 2015; 17(4): e26006.

Jeonghyeon Bak, et al.

Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NK-Kappa B and MAPK Signaling Pathways

Oxid Med Cell Longev. 2016; 2016: 3935841.

Seong-Soo Roh, et al.

Low-Molecular-Weight Oligonol, a Polyphenol Derived from Lychee Fruit, Attenuates Experimental Reflux Esophagitis and HCl/Ethanol-Induced Gastric Ulcer

J Med Food. 2017; 20(12): 1214-1221.

澁川卓実ら

ポリフェノール水溶液による二酸化窒素の吸収

化学工学論文集. 2011; 37(2): 162-166.

若命浩二ら

各種天然食品素材等を配合した精力改善（性機能改善）EDドリンクの開発の試み

FOOD STYLE 21. 2011; 165: 41-43.

Jae Hyun Ahn, et al.

Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell

Nutr Res Pract. 2015; 9(2): 123-8.

鈴木克彦ら

新規好中球機能検査法によるオリゴノールの機能解析

日本補完代替医療学会誌. 2013; 10(1): 59-62.

Naeun Lee, et al.

Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes

Hum Immunol. 2016; 77(6): 512-5.

内田努ら

Effect of Polyphenols on the Ice-Nucleation Activity of Ultrafine Bubbles

Nanomaterials. 2023; 13(1): 205.

藤川清三ら

過冷却促進物質の研究の現状

不凍タンパク質の機能と応用. 2018: 180-190.

藤川清三ら

Supercooling-Promoting (Anti-ice Nucleation) Substances

Survival Strategies in Extreme Cold and Desiccation. 2018: 289-320.

Toshie Koyama, et al.

Anti-ice nucleating activity of polyphenol compounds against silver iodide

Cryobiology. 2014; 69(2): 223-8.

Chikako Kuwabara, et al.

Analysis of supercooling activity of tannin-related polyphenols

Cryobiology. 2013; 67(1): 40-9.

Xiao Chen, et al.

Flavanol-rich lychee fruit extract substantially reduces progressive cognitive and molecular deficits in a triple-transgenic animal model of Alzheimer disease

Nutr Neurosci. 2019; 1-15.

Yoon Young Choi, et al.

Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer’s mouse model

Nutr Res. 2014; 34(7): 595-603.

櫻井拓也ら

Oligomerized lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells

Br J Nutr. 2013; 110(9): 1549-58.

Miseon Kim, et al.

Oligonol, a Low Molecular Weight Polyphenol, Enhances Apoptotic Cell Death in Ovarian Cancer Cells via Suppressing NF-κB Activation

Nutr Cancer. 2019; 71(1): 141-148.

Sung-Jae Lee, et al.

Inhibition of Lung Metastasis in Mice by Oligonol

Phytother Res. 2009; 23(7): 1043-6.

山西涼太ら

The Anti-inflammatory Effects of Flavanol-rich Lychee Fruit Extract in Rat Hepatocytes

PLoS One. 2014; 9(4): e93818.

北舘健太郎ら

Thirteen-week oral dose toxicity study of Oligonol containing oligomerized polyphenols extracted from lychee and green tea

Regul Toxicol Pharmacol. 2014; 68(1): 140-6.

Mahesh Thirunavukkarasu, et al.

Safety of oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on liver, kidney and heart function in rats

Toxicol Mech Methods. 2012; 22(7): 555-9.

藤井創ら

Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts

Food Chem Toxicol. 2008; 46(12): 3553-62.